Objective : The goal of this study was to identify the proportion of patients with intentional and unintentional drug poisonings and determine demographic and other factors having significant association with type of poisoning. Material and Methods : The study was conducted at the Emergency Department of Mubarak Al Kabeer hospital, Kuwait from June 2010 to December 2012. Data were collected using a pre-tested structured questionnaire with a consent form and patients were followed until discharge from the hospital. The underlying cause of the admission was identified to be drug poisoning based on patient interviews and evaluation. Results : A total of 116 patients were admitted due to drug poisoning. The majority of 63(54.3%) patients belonged to the age group of 12-29 years. Sixty seven (57.8%) patients had intentional poisoning. The causes for unintentional poisoning were, wrong dose 22(44.9%), duplicate therapy14 (28.6%) and drug-drug interactions 13(26.5%). There is significant difference between the groups having intentional and unintentional drug poisoning (p