Household Transmission of Severe Acute Respiratory Syndrome Coronavirus-2 in the United States
| العنوان: | Household Transmission of Severe Acute Respiratory Syndrome Coronavirus-2 in the United States |
|---|---|
| المؤلفون: | Mark Fajans, Allison Binder, Hannah E. Reses, Natalie J. Thornburg, Michelle Banks, Ian W Pray, Brandi Freeman, Angela Dunn, Almea Matanock, Tair Kiphibane, Sherry Yin, Sanjib Bhattacharyya, Katherine A. Battey, Lisa A. Mills, Hannah L Kirking, Daniel Owusu, Anna R Yousaf, Cuc H. Tran, Radhika Gharpure, Erin E. Conners, Victoria T Chu, Lucia C. Pawloski, Aron J. Hall, Henry Njuguna, Patrick Dawson, Sean A Buono, Ryan P Westergaard, Jeni Vuong, Christopher J. Gregory, Michelle O'Hegarty, Jared R. Rispens, Sarah Willardson, Susan I. Gerber, Nathaniel M. Lewis, Elizabeth A. Dietrich, Rebecca J Chancey, Kim Christensen, Lindsey Page, Lindsey M. Duca, Ashutosh Wadhwa, Scott A Nabity, Perrine Marcenac, Ann Christiansen, John C. Watson, Amy C Schumacher, Phillip P. Salvatore, Rebecca L. Laws, Elizabeth M Rabold, Victoria L. Fields, Eric Pevzner, Garrett Fox, Dongni Ye, Jacqueline E. Tate, Mary Pomeroy, Trivikram Dasu, Sandra Lester |
| المصدر: | Clinical Infectious Diseases. 73:e1805-e1813 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Transmission (medicine), business.industry, Secondary infection, Odds ratio, Confidence interval, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Infectious Diseases, El Niño, Spouse, Internal medicine, medicine, Medical history, 030212 general & internal medicine, business, Contact tracing |
| الوصف: | Background The evidence base for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is nascent. We sought to characterize SARS-CoV-2 transmission within US households and estimate the household secondary infection rate (SIR) to inform strategies to reduce transmission. Methods We recruited patients with laboratory-confirmed SARS-CoV-2 infection and their household contacts in Utah and Wisconsin during 22 March 2020–25 April 2020. We interviewed patients and all household contacts to obtain demographics and medical histories. At the initial household visit, 14 days later, and when a household contact became newly symptomatic, we collected respiratory swabs from patients and household contacts for testing by SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) and sera for SARS-CoV-2 antibodies testing by enzyme-linked immunosorbent assay (ELISA). We estimated SIR and odds ratios (ORs) to assess risk factors for secondary infection, defined by a positive rRT-PCR or ELISA test. Results Thirty-two (55%) of 58 households secondary infection among household contacts. The SIR was 29% (n = 55/188; 95% confidence interval [CI], 23%–36%) overall, 42% among children (aged Conclusions We found substantial evidence of secondary infections among household contacts. People with COVID-19, particularly those with immunocompromising conditions or those with household contacts with diabetes, should take care to promptly self-isolate to prevent household transmission. |
| تدمد: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciaa1166 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d48d72ca873f2d7a455bb70f4bb0082a https://doi.org/10.1093/cid/ciaa1166 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........d48d72ca873f2d7a455bb70f4bb0082a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
|---|---|
| DOI: | 10.1093/cid/ciaa1166 |