Obstructive Primary Bladder Neck Disease: Evaluation of the Efficacy and Safety of α1-Blockers
| العنوان: | Obstructive Primary Bladder Neck Disease: Evaluation of the Efficacy and Safety of α1-Blockers |
|---|---|
| المؤلفون: | Massimo Iafrate, A. Calpista, Walter Artibani, T. Prayer Galetti, G. Zeccolini, A. Cisternino, V. De Marco |
| المصدر: | Urologia Internationalis. 76:150-153 |
| بيانات النشر: | S. Karger AG, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Urology, MEDLINE, Disease, urologic and male genital diseases, α1 blocker, Surgery, Clinical trial, Neck of urinary bladder, Endoscopic incision, Tamsulosin, medicine, business, medicine.drug |
| الوصف: | Objective: The efficacy and safety of using α1-adrenergic blockers for treating primary bladder neck obstruction in young and middle-aged men was assessed as the first therapeutic step, before surgery, in a symptomatic non-neurogenic selected group of patients. Materials and Methods: From January 1995 to December 2001, primary bladder neck obstruction was diagnosed in 41 men whose average age was 43 years. All of them were evaluated by a complete clinical history, American Urological Association (AUA) symptom score index, physical examination, uroflowmetry, transabdominal ultrasound prostatic volume determination, ultrasound post-void residual determination, videourodynamics including pressure-flow analysis and upper urinary tract screening with renal ultrasound or an excretory urogram. A full daily dose of α1-adrenergic blockers (alfuzosin or tamsulosin) was administered for at least 6 months. Successful treatment was defined as improved symptoms, voiding diary, maximum flow rate and pressure-flow parameters. Patients who did not gain improvement of symptoms with pharmacological treatment were offered surgery. Results: Overall, pharmacological treatment was successful in 29/41 patients (70.7%) whereas bladder neck endoscopic incision was mandatory in 12/41 (29.3%). Conclusions: α1-Blockers were effective and safe for treating young and middle-aged men with symptomatic bladder neck obstruction. |
| تدمد: | 1423-0399 0042-1138 |
| DOI: | 10.1159/000090879 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::cfc3fbc58aeee075f3e5ba90c8805486 https://doi.org/10.1159/000090879 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........cfc3fbc58aeee075f3e5ba90c8805486 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230399 00421138 |
|---|---|
| DOI: | 10.1159/000090879 |