0172 Behavioral Drive in Familial Natural Short Sleepers and Their Unaffected Family Members
| العنوان: | 0172 Behavioral Drive in Familial Natural Short Sleepers and Their Unaffected Family Members |
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| المؤلفون: | Liza Ashbrook, Andrew Krystal, Ying-Hui Fu, Louis Ptacek |
| المصدر: | Sleep. 45:A79-A80 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Physiology (medical), Neurology (clinical) |
| الوصف: | Introduction Those with familial natural short sleep (FNSS) report short sleep duration since youth. Mutations in four different genes in five families have been described leading to this autosomal dominant sleep pattern. Individuals with FNSS also have a cluster of other traits in addition to short sleep than can be termed “behavioral drive.” Here we describe a new behavioral drive scale that aims to capture the distinct phenotype of those with FNSS. Methods Individuals reporting fewer than 6.5 hours of sleep when allowed to sleep ad libitum without any sleep-related complaint were interviewed to determine FNSS affected status from 2009 to 2021. Seven distinct non-sleep related traits were selected by consensus within the study team based on interviews with participants. Participants provided a self-rating on their degree of energy, pain tolerance, physical activity, ability to handle stress, productivity, hours working, and mental activity compared to other of the same age. Symptoms of mania and ADHD were also rated. Results 77 individuals meeting criteria for FNSS were enrolled along with 27 unaffected family members. Compared to unaffected family members, those with FNSS reported significantly more energy, pain tolerance, physical activity, ability to sit still, hours working, and mental activity. There was a trend towards significance for productivity. Four features of bipolar disorder were also queried, reckless decisions, rapid speech, impulsivity, and irritability, and there was no significant difference for any of these items between groups. Two symptoms of ADHD were included, concentration trouble and ability to sit still. Those with FNSS reported less concentration trouble than peers and an equal ability to sit still. Conclusion Those with FNSS have multiple distinct traits including greater energy, pain tolerance, physical activity, ability to handle stress, hours working, and mental activity compared to unaffected family. When grouped together these traits can be titled “behavioral drive.” Further work will aim for validation of this scale in gene carriers and larger populations. Support (If Any) This work was supported by NIH grants NS099333, NS072360 and NS104782 to L.J.P. and Y-H.F., and by the William Bowes Neurogenetics Fund to L.J.P. and Y.H.F. |
| تدمد: | 1550-9109 0161-8105 |
| DOI: | 10.1093/sleep/zsac079.170 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::cef7486ba7a8d3a59fc36de8cce4e731 https://doi.org/10.1093/sleep/zsac079.170 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........cef7486ba7a8d3a59fc36de8cce4e731 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15509109 01618105 |
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| DOI: | 10.1093/sleep/zsac079.170 |