N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*1
| العنوان: | N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*1 |
|---|---|
| المؤلفون: | Tracie E. Bunton, Marilyn J. Wolfe |
| المصدر: | Toxicologic Pathology. 24:323-330 |
| بيانات النشر: | SAGE Publications, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Hemangiopericytoma, Pathology, medicine.medical_specialty, 040301 veterinary sciences, Oryzias, 04 agricultural and veterinary sciences, Cell Biology, Biology, Toxicology, medicine.disease, biology.organism_classification, 030226 pharmacology & pharmacy, Pathology and Forensic Medicine, 0403 veterinary science, stomatognathic diseases, 03 medical and health sciences, 0302 clinical medicine, Hemangiosarcoma, medicine, Carcinoma, Neoplasm, Sarcoma, Teratoma, Rhabdomyosarcoma, Molecular Biology |
| الوصف: | To test the sensitivity of the small fish species Oryzias latipes to the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), medaka were exposed at 15 days of age to 30 mg/L for 1 hr and followed for up to 16 mo. One hundred neoplasms were diagnosed in 84 of 213 exposed fish, with approximately equal percentages in males and females. Many neoplasms (62%) were of mesenchymal origin and were categorized as blood vascular neoplasms (hemangioma and hemangiosarcoma), invasive sarcomas, and scale-associated neoplasms. Invasive sarcomas included rhabdomyosarcoma, fascial sarcoma, hemangiopericytoma, and undifferentiated sarcoma. A scale-associated neoplasm, termed lepidocytoma, was an unusual neoplasm of scale anlage. Thyroid follicular neoplasms, with a 100% incidence in males, and pancreatic acinar carcinoma were the most common epithelial tumors. Neoplasms of the gills, swim bladder, and olfactory epithelium were also seen as well as teratoma with mixed epithelial and mesenchymal components. The study showed a broad range of neoplasms induced by MNNG in medaka, with a tissue distribution that might support direct action on exposed tissues. |
| تدمد: | 1533-1601 0192-6233 |
| DOI: | 10.1177/019262339602400308 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::cbf1aed3a8e6f78045757ce5a71ac1fc https://doi.org/10.1177/019262339602400308 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........cbf1aed3a8e6f78045757ce5a71ac1fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15331601 01926233 |
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| DOI: | 10.1177/019262339602400308 |