Three New Peroxides from the Sponge Plakinastrella Species
| العنوان: | Three New Peroxides from the Sponge Plakinastrella Species |
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| المؤلفون: | Amy E. Wright, Peter J. McCarthy, Shirley A. Pomponi, Ying Chen, Katherine Chilson, Rebecca Schimoler, Claude Selitrennikoff, K. Brian Killday |
| المصدر: | Journal of Natural Products. 64:262-264 |
| بيانات النشر: | American Chemical Society (ACS), 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Pharmacology, chemistry.chemical_classification, Organic peroxide, Chromatography, biology, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Fungi imperfecti, Pharmacognosy, biology.organism_classification, Peroxide, Analytical Chemistry, Aspergillus fumigatus, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Drug Discovery, Molecular Medicine, Phenols, Candida albicans, Lactone |
| الوصف: | Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide−lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 μg/mL (SDB) and 3.1 μg/mL (RPMI) for 3, and 25 μg/mL (SDB) and 6.25 μg/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 μg/mL. |
| تدمد: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np000368+ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::cb3318f849e2e07713da601caf10f4d6 https://doi.org/10.1021/np000368+ |
| رقم الانضمام: | edsair.doi...........cb3318f849e2e07713da601caf10f4d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206025 01633864 |
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| DOI: | 10.1021/np000368+ |