Kinetic Inertness and Electrochemical Behavior of Copper( II ) Tetraazamacrocyclic Complexes: Possible Implications for in Vivo Stability
| العنوان: | Kinetic Inertness and Electrochemical Behavior of Copper( |
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| المؤلفون: | Gary R. Weisman, Arnold L. Rheingold, Katie J. Heroux, Carolyn J. Anderson, Katrina S. Woodin, C. Andrew Boswell, Lev N. Zakharov, Weijun Niu, Sterling A. Tomellini, Edward H. Wong |
| المصدر: | European Journal of Inorganic Chemistry. 2005:4829-4833 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Aqueous solution, Inorganic chemistry, chemistry.chemical_element, Protonation, Electrochemistry, Copper, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Cyclen, Cyclam, Polymer chemistry, Carboxylate, Bifunctional |
| الوصف: | The kinetic inertness of copper(II) complexes of several carboxymethyl-armed cyclams and cyclens in 5 M HCl have been determined confirming that the complex derived from cross-bridged cyclam (Cu-CB-TE2A) is by far the most resistant to acid decomplexation. FT-IR studies in D2O solution revealed its unique resistance to full carboxylate protonation and its retention of coordination by both pendant arms even in 1 M DCl. The X-ray structure of its monoprotonated form, [Cu-CB-TE2AH]+, also established full coordination by both COO– and COOH pendant arms in the solid state. Cyclic voltammograms of four carboxymethyl pendant-armed cyclam and cyclen complexes in aqueous solution were obtained with only Cu-CB-TE2A displaying a quasi-reversible CuII/CuI reduction wave. These indicators correlate with the superior in vivo behavior of this complex and its bifunctional conjugate. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) |
| تدمد: | 1099-0682 1434-1948 |
| DOI: | 10.1002/ejic.200500579 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c970ae590a46e69ee3e188593419bf81 https://doi.org/10.1002/ejic.200500579 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........c970ae590a46e69ee3e188593419bf81 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10990682 14341948 |
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| DOI: | 10.1002/ejic.200500579 |