A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
| العنوان: | A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease |
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| المؤلفون: | Peter B. Woodbury, Eric Pfeiffer, Michael Grundman, Mary Sano, Lon S. Schneider, Melville R. Klauber, Carl W. Cotman, Leon J. Thal, John H. Growdon, Kimberly Schafer, Ronald G. Thomas, Christopher Ernesto |
| المصدر: | New England Journal of Medicine. 336:1216-1222 |
| بيانات النشر: | Massachusetts Medical Society, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | medicine.medical_specialty, Monoamine oxidase inhibitor, business.industry, Clinical Dementia Rating, medicine.drug_class, Selegiline, General Medicine, Placebo, medicine.disease, law.invention, Surgery, Clinical trial, Randomized controlled trial, law, Internal medicine, Multicenter trial, Medicine, Alzheimer's disease, business, medicine.drug |
| الوصف: | Background There is evidence that medications or vitamins that increase the levels of brain catecholamines and protect against oxidative damage may reduce the neuronal damage and slow the progression of Alzheimer's disease. Methods We conducted a double-blind, placebo-controlled, randomized, multicenter trial in patients with Alzheimer's disease of moderate severity. A total of 341 patients received the selective monoamine oxidase inhibitor selegiline (10 mg a day), alpha-tocopherol (vitamin E, 2000 IU a day), both selegiline and alpha-tocopherol, or placebo for two years. The primary outcome was the time to the occurrence of any of the following: death, institutionalization, loss of the ability to perform basic activities of daily living, or severe dementia (defined as a Clinical Dementia Rating of 3). Results Despite random assignment, the base-line score on the Mini–Mental State Examination was higher in the placebo group than in the other three groups, and this variable was highly predictive of the pr... |
| تدمد: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm199704243361704 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c8b90d892dbeb935be8a97a07417c5bf https://doi.org/10.1056/nejm199704243361704 |
| رقم الانضمام: | edsair.doi...........c8b90d892dbeb935be8a97a07417c5bf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334406 00284793 |
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| DOI: | 10.1056/nejm199704243361704 |