Impact of Pregnancy on Ventricular Strain in Women with Repaired Tetralogy of Fallot
| العنوان: | Impact of Pregnancy on Ventricular Strain in Women with Repaired Tetralogy of Fallot |
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| المؤلفون: | Julia A. Graf, Valeria E. Duarte, Sarah Rae Easter, Kimberlee Gauvreau, Katherine E. Economy, David M. Harrild, Sheila C. Drakeley, Matthew Carazo, Anne Marie Valente |
| المصدر: | Pediatric Cardiology. 41:1795-1799 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pregnancy, Ejection fraction, business.industry, Strain (injury), 030204 cardiovascular system & hematology, Vascular surgery, medicine.disease, Cardiac surgery, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Pulmonary Valve Replacement, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, Postpartum period, Tetralogy of Fallot |
| الوصف: | Increasing numbers of women with repaired tetralogy of Fallot (rTOF) are reaching reproductive age and seek counseling regarding their cardiovascular risks related to pregnancy. Therefore, the aim of this study was to characterize changes in left ventricular (LV) strain in women with rTOF during pregnancy and in the postpartum period. Seventeen pregnancies in women with rTOF were included (mean age at repair = 3.2 years ± 5.5 years; mean age at delivery = 32.7 ± 4 years). Echocardiograms from three time periods were analyzed; baseline (prior to conception or in the first trimester), third trimester, and 4–6 weeks postpartum. Sixty-five percent of the patients had at least mild pulmonary regurgitation. Eight patients (47%) had undergone at least one pulmonary valve replacement. There were no changes in LV ejection fraction (EF) or circumferential strain across the three time periods. Significant differences were present in longitudinal strain within the three time points (p = 0.01). Postpartum strain decreased in magnitude compared to the third trimester value (− 17.7 ± 4.1 vs. − 21 ± 5, p-value = 0.003) but was not different when compared to baseline strain (− 17.7 ± 4.1 vs. − 19.4 ± 3.4; p-value = 0.15). In conclusion, in women with rTOF, changes in longitudinal strain were observed during pregnancy with a return to baseline after delivery; EF did not change. These findings provide evidence that pregnancy does not adversely impact LV mechanics in the short term in this potentially vulnerable patient population. |
| تدمد: | 1432-1971 0172-0643 |
| DOI: | 10.1007/s00246-020-02447-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c424a553deff0b4101eefa71390c2f0b https://doi.org/10.1007/s00246-020-02447-3 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........c424a553deff0b4101eefa71390c2f0b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321971 01720643 |
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| DOI: | 10.1007/s00246-020-02447-3 |