Effect of Drug Loading and Process Temperature on Physicochemical Properties of Manidipine Hydrochloride Solid Dispersion
| العنوان: | Effect of Drug Loading and Process Temperature on Physicochemical Properties of Manidipine Hydrochloride Solid Dispersion |
|---|---|
| المؤلفون: | Benchawan Chamsai, Pornsak Sriamornsak |
| المصدر: | Advanced Materials Research. 1060:176-179 |
| بيانات النشر: | Trans Tech Publications, Ltd., 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Chromatography, Materials science, Organic solvent, General Engineering, Polyethylene glycol, Amorphous solid, chemistry.chemical_compound, Chemical engineering, chemistry, Scientific method, PEG ratio, Manidipine hydrochloride, Dispersion (chemistry), Solid solution |
| الوصف: | Binary solid dispersions of manidipine hydrochloride (MDP) and polyethylene glycol (PEG) 4000 are prepared by melting method. Drug loading and process temperature are varied in the range of 5-30% and 150-210°C, respectively. After melting, only the formulation using 5% MDP and process temperature of 210°C showed yellow clear solution and halo pattern of powder X-ray diffractograms with the absence of peaks. These results indicated that the higher process temperature (210°C) can melt all MDP powders and provide the amorphous product. Moreover, only the higher carrier content can change the crystalline form of MDP to the amorphous form. A clear, solid solution could not be prepared when the drug loading was higher than 5%. In this study, the melting technique avoiding the use of organic solvent was successfully applied to prepared binary solid dispersion. |
| تدمد: | 1662-8985 |
| DOI: | 10.4028/www.scientific.net/amr.1060.176 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c35579c5b29b72fd58f8ab349a311ee6 https://doi.org/10.4028/www.scientific.net/amr.1060.176 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........c35579c5b29b72fd58f8ab349a311ee6 |
| قاعدة البيانات: | OpenAIRE |
كن أول من يترك تعليقا!