Binary solid dispersions of manidipine hydrochloride (MDP) and polyethylene glycol (PEG) 4000 are prepared by melting method. Drug loading and process temperature are varied in the range of 5-30% and 150-210°C, respectively. After melting, only the formulation using 5% MDP and process temperature of 210°C showed yellow clear solution and halo pattern of powder X-ray diffractograms with the absence of peaks. These results indicated that the higher process temperature (210°C) can melt all MDP powders and provide the amorphous product. Moreover, only the higher carrier content can change the crystalline form of MDP to the amorphous form. A clear, solid solution could not be prepared when the drug loading was higher than 5%. In this study, the melting technique avoiding the use of organic solvent was successfully applied to prepared binary solid dispersion.