Under single-step and double-step homogenization conditions, the precipitation behavior of Al3Zr dispersoids and its effects on the microstructures and tensile properties of an Al-3.5Cu-1.5Li-0.11Zr alloy were investigated in the current study. It was found that a double-stage homogenization (460 °C/16 h, 520 °C/24 h) enhanced the uniformity of the Al3Zr dispersoids distribution compared with the single-stage homogenized samples. Al3Zr particles which are coherent with the matrix would inhibit the movement of dislocation induced by stress and also the migration of sub-grain boundary and grain boundary induced by thermal activation. The finer particle size and distribution more diffuse of Al3Zr particles reduced recrystallization during hot rolling and solution heat treatment, improving the tensile properties of the as-aged sample.