IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma
| العنوان: | IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma |
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| المؤلفون: | Caitlin Obminski, Paul M. O'Byrne, Damian Tworek, Gail M. Gauvreau, Adrian J Baatjes, Steven G. Smith, Tara Scime, Brittany M. Salter, Richard M. Watson |
| المصدر: | American Journal of Respiratory and Critical Care Medicine. 193:957-964 |
| بيانات النشر: | American Thoracic Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Pulmonary and Respiratory Medicine, Myeloid, Innate immune system, business.industry, Receptor expression, medicine.medical_treatment, TLR9, hemic and immune systems, Critical Care and Intensive Care Medicine, medicine.disease, medicine.disease_cause, respiratory tract diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Allergen, Cytokine, 030228 respiratory system, Immunology, medicine, business, Receptor, Asthma |
| الوصف: | Rationale: IL-25 is an epithelial-derived cytokine, whose effects are mediated by the IL-25 receptor (IL-17RB), and that has been implicated in the pathogenesis of allergic disease and airway viral responses. Airway myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) are professional antigen-presenting cells. pDCs may play a protective role in asthma and are key players in the innate immune response through recognition of microbial products via Toll-like receptors (TLRs). The effects of inhaled allergens on the expression of IL-17RB by mDCs and pDCs, and the effects of IL-25 on pDCs, are unknown.Objectives: To evaluate allergen-induced changes in IL-17RB expression by mDCs and pDCs and to investigate the effects of IL-25 on pDCs.Methods: Patients with mild atopic asthma (n = 13) were challenged with inhaled allergen. Blood and sputum DCs were enumerated and IL-17RB expression was determined by flow cytometry before and 7 and 24 hours after allergen challenge. The effects of IL-25 on pDC... |
| تدمد: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.201509-1751oc |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::beab7d8e053cae16e886ce1778831f5f https://doi.org/10.1164/rccm.201509-1751oc |
| رقم الانضمام: | edsair.doi...........beab7d8e053cae16e886ce1778831f5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354970 1073449X |
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| DOI: | 10.1164/rccm.201509-1751oc |