Ex vivo evaluation of celecoxib release from ionic liquid-based microemulsions and microemulgels for topical applications
| العنوان: | Ex vivo evaluation of celecoxib release from ionic liquid-based microemulsions and microemulgels for topical applications |
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| المؤلفون: | Alireza Salabat, Elham Parsi |
| المصدر: | Journal of the Iranian Chemical Society. 18:1355-1361 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Franz diffusion cell, 010405 organic chemistry, Diffusion, General Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Ionic liquid, Celecoxib, medicine, Microemulsion, Particle size, Isopropyl myristate, Ex vivo, Nuclear chemistry, medicine.drug |
| الوصف: | The aim of this study was to introduce new ionic liquid (IL)-based microemulsions and microemulgels as topical delivery systems for celecoxib. Ex-vivo diffusion of celecoxib loaded in IL-based microemulsions and microemulgels through the rat skin by using Franz diffusion cell was investigated and compared with traditional microemulsions. The investigated systems composed of the same nonionic surfactant/co-surfactant of tween-80/transcutol®P, and different oil phases of [BMIM][PF6], [OMIM][PF6] and isopropyl myristate, for construction of ILs/W and O/W microemulsions. The particle size of the ILs/W and O/W microemulsion systems was determined by DLS method. The ex-vivo release results of ILs/W and O/W formulations, at similar conditions, showed that the celecoxib permeability of the ILs/W formulations is more than that of the O/W formulation, either as microemulsion or as microemulgel. As an interesting result, the celecoxib release percent and release rate from the ILs/W systems was more and faster than the O/W system. The kinetic mechanism for ILs/W systems had followed from first-order model and for O/W systems followed Higuchi zero-order model. |
| تدمد: | 1735-2428 1735-207X |
| DOI: | 10.1007/s13738-020-02122-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::bde38dcec426c71fbfceb9910c81e8db https://doi.org/10.1007/s13738-020-02122-7 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........bde38dcec426c71fbfceb9910c81e8db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17352428 1735207X |
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| DOI: | 10.1007/s13738-020-02122-7 |