Peptide Quinoline Conjugates: A New Class of RNA-Binding Molecules
| العنوان: | Peptide Quinoline Conjugates: A New Class of RNA-Binding Molecules |
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| المؤلفون: | Peter A. Beal, Malathy Krishnamurthy, Barry D. Gooch |
| المصدر: | Organic Letters. 6:63-66 |
| بيانات النشر: | American Chemical Society (ACS), 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Organic Chemistry, Quinoline, Intercalation (chemistry), RNA, Peptide, Biochemistry, Combinatorial chemistry, Amino acid, chemistry.chemical_compound, chemistry, Molecule, Physical and Theoretical Chemistry, Conjugate |
| الوصف: | A synthesis of 4,8-disubstituted 2-phenylquinoline amino acids is reported with the incorporation of one example into a peptide by solid-phase synthesis. The phenylquinoline-containing peptide binds an RNA target with nanomolar affinity (KD = 208 nM). The strategy can be used to prepare a variety of 2-substituted quinoline amino acids for alteration of affinity in intercalator peptides. Since quinolones represent an important class of antibacterials, these compounds may be useful in the discovery of new antibacterial agents. |
| تدمد: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol036094+ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b919d5a877898ab77af2861bf058f2b3 https://doi.org/10.1021/ol036094+ |
| رقم الانضمام: | edsair.doi...........b919d5a877898ab77af2861bf058f2b3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15237052 15237060 |
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| DOI: | 10.1021/ol036094+ |