A case of mandibular osteonecrosis possibly associated with a bisphophonate: consideration of underlying mechanisms and prevention
| العنوان: | A case of mandibular osteonecrosis possibly associated with a bisphophonate: consideration of underlying mechanisms and prevention |
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| المؤلفون: | Takefumi Oizumi, Jun Kurihara, Satoko Koeda, Yoko Takata, Hiroshi Kawamura, Kouji Yamaguchi |
| المصدر: | Japanese Journal of Oral & Maxillofacial Surgery. 54:602-606 |
| بيانات النشر: | Japanese Society of Oral and Maxillofacial Surgeons, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, Necrosis, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Mandible, Bone metastasis, Soft tissue, Physical examination, Bisphosphonate, medicine.disease, Surgery, Breast cancer, medicine, Increased bone resorption, medicine.symptom, business |
| الوصف: | There are two types of anti-bone resorptive bisphosphonates, nitrogen-containing bisphosphonates (NBPs) and non-nitrogen containing bisphosphonates (non-NBPs). Since NBPs have much stronger activities than non-NBPs, the former are widely used to treat increased bone resorption (including bone metastasis). In addition to the known inflammatory side effects of NBPs, recent clinical application has been associated with an unexpected side effects, necrosis, and subsequent exposure of jaw bones. We report mandibular osteonecrosis in a 63-year-old woman who had breast cancer with bone metastasis. She was referred to our clinic because of oral pain. The mandible (partly exposed because of necrosis) was surrounded by inflamed soft tissue. She had been taking pamidronate (an NBP) once a month (45mg) for 35 months. In Europe and the United States, several thousand cases of NBP-related osteonecrosis have been reported during the past 3 years. On clinical examination, we diagnosed NBP-related osteonecrosis. This case emphasizes the importance of close communication between oncologists and dentists before and during treatment with NBP. On the basis of the current results of our basic studies of BPs, we discuss possible mechanisms underlying jaw necrosis and means of prevention. |
| تدمد: | 2186-1579 0021-5163 |
| DOI: | 10.5794/jjoms.54.602 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b84a7755f4814dd535c5437e14e2acc9 https://doi.org/10.5794/jjoms.54.602 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........b84a7755f4814dd535c5437e14e2acc9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21861579 00215163 |
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| DOI: | 10.5794/jjoms.54.602 |