Human immune response to multiple injections of murine monoclonal IgG
| العنوان: | Human immune response to multiple injections of murine monoclonal IgG |
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| المؤلفون: | D L Shawler, R M Bartholomew, L M Smith, R O Dillman |
| المصدر: | The Journal of Immunology. 135:1530-1535 |
| بيانات النشر: | The American Association of Immunologists, 1985. |
| سنة النشر: | 1985 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Murine monoclonal antibody infusions in humans should induce a human anti-mouse immunoglobulin (mIgG) immune response, especially if multiple infusions over an extended period of time are necessary for therapeutic efficacy. We have administered multiple infusions of the murine monoclonal antibody T101 to patients with cutaneous T cell lymphoma (CTCL) or chronic lymphocytic leukemia (CLL). Five of 10 CTCL patients, compared with zero of six CLL patients, developed antibodies to mIgG. In those CTCL patients who did not demonstrate anti-mIgG antibodies, we were unable to correlate the lack of response to any of a large number of clinical parameters. Anti-mIgG antibodies were of both the mu and gamma isotypes and were detectable 14 days after the first infusion. Multiple infusions were associated with elevated titers. The anti-idiotypic portion of the anti-mIgG titer steadily increased with each infusion until eventually, in one patient receiving eight weekly infusions, well over one-half the serum anti-mIgG recognized only T101 and not four other murine IgG2AK antibodies tested. To increase our confidence in these findings, four separate assay systems were used to make these determinations. The identification of anti-idiotype antibodies as the dominant species of the immune response to multiple infusions of murine monoclonal antibody has major implications for future work with monoclonal antibodies. Although it has been suggested that human monoclonal antibodies would obviate an immune response, our work implies that such antibodies might still induce anti-idiotype antibodies if multiple infusions are administered. |
| تدمد: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.135.2.1530 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b4ceb988f4f2687fe2019b09972fd71a https://doi.org/10.4049/jimmunol.135.2.1530 |
| رقم الانضمام: | edsair.doi...........b4ceb988f4f2687fe2019b09972fd71a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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| DOI: | 10.4049/jimmunol.135.2.1530 |