Comparative toxicity and distribution of InCl3and In2O3nanoparticles in rats
| العنوان: | Comparative toxicity and distribution of InCl3and In2O3nanoparticles in rats |
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| المؤلفون: | Asghar Amiri |
| المصدر: | Toxin Reviews. 35:116-120 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | inorganic chemicals, medicine.medical_treatment, Intraperitoneal injection, Inorganic chemistry, Oxide, chemistry.chemical_element, Spleen, 02 engineering and technology, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Indium(III) chloride, Kidney, digestive, oral, and skin physiology, respiratory system, 021001 nanoscience & nanotechnology, Copper, medicine.anatomical_structure, 030228 respiratory system, chemistry, Toxicity, 0210 nano-technology, Indium, Nuclear chemistry |
| الوصف: | Recent studies have reported that metal oxide nanoparticles had potential adverse effects. In this research, the tissue distribution and toxic effects of administered InCl3 (bulk) and indium (III) oxide Nanoparticles (In2O3-NPs < 45 nm, BET of 43.6 m2/g and average hydrodynamic diameter of 79.97 nm) were investigated. Male Wistar rats were treated with a single intraperitoneal injection of InCl3 (bulk) and In2O3-NPs (2 mg/kg body weight, daily) for four consecutive weeks. Indium, copper and iron concentrations were measured by using ICP-OES. The indium levels were highest in the liver, followed in decreasing order by the levels in the spleen, kidney and intestine. The concentration of indium in In2O3-NPs exposed rats was more than InCl3 group and indium exposure caused significant decrease on Hb, RBC levels, PLT count and copper and iron concentrations in organs, which is probably due to an interference that could take place by indium (III) through iron (III) uptake mechanism. |
| تدمد: | 1556-9551 1556-9543 |
| DOI: | 10.1080/15569543.2016.1178145 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b4bd7c6d5a6cac4bf8c16d663662fff8 https://doi.org/10.1080/15569543.2016.1178145 |
| رقم الانضمام: | edsair.doi...........b4bd7c6d5a6cac4bf8c16d663662fff8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15569551 15569543 |
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| DOI: | 10.1080/15569543.2016.1178145 |