Initial Experience with Volumetric 68Ga-PSMA I&T PET/CT for Assessment of Whole-Body Tumor Burden as a Quantitative Imaging Biomarker in Patients with Prostate Cancer
| العنوان: | Initial Experience with Volumetric 68Ga-PSMA I&T PET/CT for Assessment of Whole-Body Tumor Burden as a Quantitative Imaging Biomarker in Patients with Prostate Cancer |
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| المؤلفون: | Tobias L. Ross, Hans-Jürgen Wester, Christoph Henkenberens, Jan M Sohns, Hans Christiansen, Sebastian Schmuck, Thorsten Derlin, Christoph A. J. von Klot, Frank M. Bengel |
| المصدر: | Journal of Nuclear Medicine. 58:1962-1968 |
| بيانات النشر: | Society of Nuclear Medicine, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | medicine.medical_specialty, PET-CT, business.industry, Surrogate endpoint, Prostatectomy, medicine.medical_treatment, Whole body imaging, Retrospective cohort study, urologic and male genital diseases, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Prostate cancer, Prostate-specific antigen, 0302 clinical medicine, 030220 oncology & carcinogenesis, Medicine, Biomarker (medicine), Radiology, Nuclear Medicine and imaging, Radiology, business, Nuclear medicine |
| الوصف: | A quantitative imaging biomarker is desirable to provide a comprehensive measure of whole-body tumor burden in patients with metastatic prostate cancer, and to standardize the evaluation of treatment-related changes. Therefore, we evaluated whether prostate-specific membrane antigen (PSMA) ligand PET/CT may be applied to provide PSMA-derived volumetric parameters for quantification of whole-body tumor burden. Methods: One hundred one patients who underwent 68Ga-PSMA I&T PET/CT because of increasing prostate-specific antigen (PSA) levels after radical prostatectomy were included in this retrospective analysis. Tracer uptake was quantified using SUVs. Volumetric parameters, that is, PSMA-derived tumor volume (PSMA-TV) and total lesion PSMA (TL-PSMA), were calculated for each patient using a 3-dimensional segmentation and computerized volumetry technique and compared with serum PSA levels. In a group of 10 patients, volumetric parameters were applied for treatment monitoring. Results: Volumetric parameters, that is, whole-body PSMA-TV and whole-body TL-PSMA, demonstrated a statistically significant correlation with PSA levels (P < 0.0001) as a surrogate marker of tumor burden, whereas SUVmax (P = 0.22) or SUVmean (P = 0.45) did not. Treatment response and treatment failure were paralleled by concordant changes in both whole-body PSMA-TV and whole-body TL-PSMA (P = 0.02), whereas neither the change in SUVmax (P = 1.0) nor the change in SUVmean (P = 1.0) concordantly paralleled changes in PSA levels. Conclusion: PSMA-derived volumetric parameters provide a quantitative imaging biomarker for whole-body tumor burden, capable of standardizing quantitative changes in PET imaging of patients with metastatic prostate cancer and of facilitating therapy monitoring. |
| تدمد: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.117.193581 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b39ebd09e7066ff393792838a8a59187 https://doi.org/10.2967/jnumed.117.193581 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........b39ebd09e7066ff393792838a8a59187 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2159662X 01615505 |
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| DOI: | 10.2967/jnumed.117.193581 |