Prognostic Value ofEGFRExon-20 Insertions in Czech Patients With Advanced Non-small Cell Lung Cancer
| العنوان: | Prognostic Value ofEGFRExon-20 Insertions in Czech Patients With Advanced Non-small Cell Lung Cancer |
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| المؤلفون: | Marketa Cernovska, Leona Koubková, Kristina Sandstrom, Jana Krejčí, Martin Svaton, Monika Bratová, Jiri Blazek, Jana Skrickova, P. Opálka, Helena Čoupková, Michal Hrnčiarik, Ondrej Fischer, Karolina Hurdalkova, Daniel Dolezal, Tana Tuzova, Magda Barinova, Milada Zemanova, Péter Kunovszki, Lubos Holubec, Miloš Pešek, P. Mahadevia |
| المصدر: | Anticancer Research. 41:5625-5634 |
| بيانات النشر: | Anticancer Research USA Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Mutation, biology, business.industry, Retrospective cohort study, General Medicine, medicine.disease_cause, medicine.disease, Exon, Internal medicine, Cohort, medicine, biology.protein, Non small cell, Epidermal growth factor receptor, business, Lung cancer, Tyrosine kinase |
| الوصف: | Background/aim Per literature, patients with epidermal growth factor receptor (EGFR) exon-20 insertions respond poorly to tyrosine kinase inhibitors (TKIs). This study analyzed real-world data to examine the prognostic and predictive value of these mutations. Patients and methods We conducted a retrospective cohort study using Czech TULUNG Registry data, with data on multiple mutation types, collected in 2011-2020. Results We analyzed 554 (95.85%) patients with EGFR exon-19 deletions or exon-21 L858R substitutions and 24 (4.15%) patients with exon-20 insertions who received first-line high-value therapies. We summarized clinical characteristics and outcomes in all patients and by cohort. The risk of progression was statistically significantly higher (86%) in the exon-20 insertion cohort compared to the cohort with other mutations. Although not statistically significant, the risk of death was 44% higher in patients with exon-20 insertions. Conclusion Advanced NSCLC patients with rare EGFR exon-20 insertions have a high risk of progression. |
| تدمد: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.15378 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::aba859470439e22e1b459a0e725153a0 https://doi.org/10.21873/anticanres.15378 |
| رقم الانضمام: | edsair.doi...........aba859470439e22e1b459a0e725153a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
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| DOI: | 10.21873/anticanres.15378 |