Abstract 838: Effect of tumor treating fields on cell proliferation and synergistic antitumor efficacy in combination with ionizing radiation
| العنوان: | Abstract 838: Effect of tumor treating fields on cell proliferation and synergistic antitumor efficacy in combination with ionizing radiation |
|---|---|
| المؤلفون: | Yunhui Jo, Jiwon Sung, Myonggeun Yoon, Eun Ho Kim, Hyo Sook Song |
| المصدر: | Cancer Research. 77:838-838 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cancer Research, Oncology, Cell growth, Chemistry, Cancer research, Ionizing radiation |
| الوصف: | Alternating electric fields at an intermediate frequency (100~300 kHz), called tumor treating fields (TTFs), are reported to interrupt the process of mitosis via apoptosis and to act as an inhibitor of cell proliferation. Although the presence of an antimitotic effect of TTFs has been widely reported, the efficacy of TTFs is still controversial issue among medical experts. To resolve this controversial issue, the comparison study between the effects of TTFs and the effect of other conventional cancer treatment techniques need to be carried out. In this study, experimental evidence of the synergistic antimitotic effect of TTFs in combination with ionizing radiation (IR) is reported. For these experiments, aggressive brain cancer cells, glioblastoma multiforme (GBM) cells (U373 and U87), were treated either with TTFs alone, with IR alone or with TTFs followed by ionizing radiation (IR). The percentages of cell apoptosis, DNA damage, and mitotic abnormalities were increased by the application of TTFs alone and its quantity was markedly increased when TTFs were combined with IR. Our results also suggested that radiotherapy together with TTFs may be clinically beneficial since the combination treatment seemed to synergistically suppress both cell migration and invasion, based on the inhibition of MMP-9 and vimentin. Citation Format: Eun Ho Kim, Yunhui Jo, Jiwon Sung, Hyo Sook Song, Myonggeun Yoon. Effect of tumor treating fields on cell proliferation and synergistic antitumor efficacy in combination with ionizing radiation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 838. doi:10.1158/1538-7445.AM2017-838 |
| تدمد: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.am2017-838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a940538a55a382be005118963dc5a18e https://doi.org/10.1158/1538-7445.am2017-838 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........a940538a55a382be005118963dc5a18e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
|---|---|
| DOI: | 10.1158/1538-7445.am2017-838 |