Multitier mechanics control stromal adaptations in the swelling lymph node
| العنوان: | Multitier mechanics control stromal adaptations in the swelling lymph node |
|---|---|
| المؤلفون: | Frank P. Assen, Jun Abe, Miroslav Hons, Robert Hauschild, Shayan Shamipour, Walter A. Kaufmann, Tommaso Costanzo, Gabriel Krens, Markus Brown, Burkhard Ludewig, Simon Hippenmeyer, Carl-Philipp Heisenberg, Wolfgang Weninger, Edouard Hannezo, Sanjiv A. Luther, Jens V. Stein, Michael Sixt |
| المصدر: | Nature Immunology. 23:1246-1255 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase more than tenfold in size within a few days. Here, we characterized the biomechanics of LN swelling on the cellular and organ scale. We identified lymphocyte trapping by influx and proliferation as drivers of an outward pressure force, causing fibroblastic reticular cells of the T-zone (TRCs) and their associated conduits to stretch. After an initial phase of relaxation, TRCs sensed the resulting strain through cell matrix adhesions, which coordinated local growth and remodeling of the stromal network. While the expanded TRC network readopted its typical configuration, a massive fibrotic reaction of the organ capsule set in and countered further organ expansion. Thus, different fibroblast populations mechanically control LN swelling in a multitier fashion. |
| تدمد: | 1529-2916 1529-2908 |
| DOI: | 10.1038/s41590-022-01257-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a7fc21304d69d6ec029ae8be77a22618 https://doi.org/10.1038/s41590-022-01257-4 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........a7fc21304d69d6ec029ae8be77a22618 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
|---|---|
| DOI: | 10.1038/s41590-022-01257-4 |