Responses to saline drinking water in offspring born to ewes fed high salt during pregnancy

التفاصيل البيبلوغرافية
العنوان: Responses to saline drinking water in offspring born to ewes fed high salt during pregnancy
المؤلفون: Dean Revell, David G. Masters, Dominique Blache, S.N. Digby
المصدر: Small Ruminant Research. 91:87-92
بيانات النشر: Elsevier BV, 2010.
سنة النشر: 2010
مصطلحات موضوعية: medicine.medical_specialty, Fetus, Pregnancy, Aldosterone, Offspring, animal diseases, medicine.medical_treatment, Area under the curve, respiratory system, Biology, Saline water, medicine.disease, Excretion, chemistry.chemical_compound, Endocrinology, Food Animals, chemistry, Internal medicine, parasitic diseases, medicine, Animal Science and Zoology, Saline
الوصف: We have studied the fetal programming of lambs born to ewes exposed to high salt during pregnancy. In the present study, we hypothesise that salt-programmed lambs may not need to drink as much saline water as control lambs and that voluntary feed intake of salt-programmed lambs would be reduced. We used two groups of lambs born to ewes fed either a high salt (13% NaCl) diet during pregnancy (S-lambs; n = 12) or control animals born to ewes fed a conventional (0.5% NaCl) diet during pregnancy (C-lambs; n = 12). Animals were offered ad libitum amounts of saline drinking water containing 1.5% NaCl for 2 days. Results indicated that there was a significant difference between fetal origin of the lamb (i.e. between C and S-lambs) and time (day 1 and 2) on water intake (P = 0.055), urinary output (P = 0.002), and sodium excretion (P = 0.002). There was an interaction between fetal origin of the lambs and time (day 1 and 2) on the area under the curve (AUC) for the plasma concentration of aldosterone (P = 0.017). Aldosterone concentration for C-lambs ranged from 167 to 196 pg/ml over days 1 and 2, whilst S-lambs reduced their aldosterone by two-thirds from day 1 to 2, from 214 ± 24 to 74 ± 8 pg/ml. A novel result was a marked difference in feed intake between C and S-lambs, where S-lambs consumed approximately 0.5 kg DM/day (35%) less than C-lambs which was associated with a decrease in insulin secretion with time in both S and C-lambs. In conclusion, feeding a high salt diet to pregnant ewes affected the physiological responses of their offspring to the consumption of saline water during a period of 2 days illustrating that fetal programming changed the temporal pattern of how the offspring adapt to a load of ingested salt.
تدمد: 0921-4488
DOI: 10.1016/j.smallrumres.2009.11.020
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a78f9279877526cc8435cce8f5e207c3
https://doi.org/10.1016/j.smallrumres.2009.11.020
Rights: CLOSED
رقم الانضمام: edsair.doi...........a78f9279877526cc8435cce8f5e207c3
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09214488
DOI:10.1016/j.smallrumres.2009.11.020