Microbial hydroxylation of 11,13-dehydrosantonin by Aspergillus nigert
| العنوان: | Microbial hydroxylation of 11,13-dehydrosantonin by Aspergillus nigert |
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| المؤلفون: | Mitsugi Iida, Koji Yamakawa, Shigeru Mineki, Kiyoshi Nishitani, Shinobu Wakuri |
| المصدر: | Journal of Fermentation and Bioengineering. 76:296-299 |
| بيانات النشر: | Elsevier BV, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Aspergillus, biology, Chemistry, Stereochemistry, Aspergillus niger, Fungi imperfecti, biology.organism_classification, Sesquiterpene lactone, Sesquiterpene, Applied Microbiology and Biotechnology, Hydroxylation, chemistry.chemical_compound, Biotransformation, Lactone, Biotechnology |
| الوصف: | The microbial transformation of a sesquiterpene lactone, 11,13-dehydro-(−)-α-santonin (DS), was carried out by 7 fungi. Although 6 of the fungi transformed the substrate into three (one fungus) or fewer (5 fungi) kinds of products, Aspergillus niger MIL 5024 gave five products including all of those produced by the others. The products were identified by UV, IR, mass, and 1 H-NMR spectroanalyses as (−)-α-santonin (P1), 11-hydroxy-(−)-α-santonin (P2), 13-hydroxy-(−)-α-santonin (P3), 3,6,9-trihydroxy-9,10- seco -selina-1,3,5(10)-trien-12-oic acid- 12,6-lactone (P4), and 8- epi -artemisin (P5). P3, a new compound, was also produced by A. niger MIL 5035, but P4 and P5 were produced only by strain MIL 5024. The biosynthetic pathway of these 5 products from DS was estimated. |
| تدمد: | 0922-338X |
| DOI: | 10.1016/0922-338x(93)90197-g |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a5f7b990e8130ca897405d380fecc9de https://doi.org/10.1016/0922-338x(93)90197-g |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........a5f7b990e8130ca897405d380fecc9de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0922338X |
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| DOI: | 10.1016/0922-338x(93)90197-g |