التفاصيل البيبلوغرافية
| العنوان: |
Flavan-3-ols from the leaves of Malaysian Uncaria longiflora var. pteropoda (Miq.) Ridsd |
| المؤلفون: |
Mazatulikhma Mat Zain, Dulcie A. Mulholland, Fatimah Salim, Rohaya Ahmad, Mohd Syafiq Mohammad Ridzuan, Moses K. Langat |
| المصدر: |
Phytochemistry Letters. 6:236-240 |
| بيانات النشر: |
Elsevier BV, 2013. |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
chemistry.chemical_classification, Circular dichroism, biology, Stereochemistry, Flavonoid, Flavan-3-ol, Plant Science, biology.organism_classification, Biochemistry, chemistry.chemical_compound, Uncaria, chemistry, Phytochemical, Flavan, Scopoletin, Oxindole, Agronomy and Crop Science, Biotechnology |
| الوصف: |
A novel flavonoid, (-)-2R,3R-3,5,4′-trihydoxyflavan-[6,7:5″, 6″]-2″-pyranone, named uncariechin (1), was isolated from the methanolic extract of the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsd. along with the known (-)-epiafzelechin (2) and (-)-epicatechin (3), methyl 4-hydroxybenzoate and 4-hydroxybenzaldehyde, four pentacyclic oxindole alkaloids, isopteropodine, pteropodine, uncarine F and isopteropodic acid, previously found in the stems, and two coumarins, scopoletin and 3,4-dihydroxy-7-methoxycoumarin. Structures of the compounds were elucidated by 1D and 2D NMR, FTIR, UV, MS, and experimental as well as calculated electronic circular dichroism (ECD) data. Compounds 2 and 3 were evaluated for their neurotoxic and neuroprotective properties against differentiated SH-SY5Y neuroblastoma cell lines using the MTS assay. Compounds 2 and 3 did not show any neurotoxic effects but showed strong protective potential against hydrogen peroxide-induced neurotoxicity with maximum cell viability at a concentration of 1 μM. © 2013 Phytochemical Society of Europe. |
| تدمد: |
1874-3900 |
| DOI: |
10.1016/j.phytol.2013.02.007 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::a368de3edd74252a93187708f0690969
https://doi.org/10.1016/j.phytol.2013.02.007 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi...........a368de3edd74252a93187708f0690969 |
| قاعدة البيانات: |
OpenAIRE |