Mutation rates in animals are closely linked with lifespan. However, a persuasive mechanism underlying the phenomena remains unknown. Free hydrogen bonding in single-stranded DNA attracts protons augmenting the formation of mutagenic HCl. Proton stress and strong acids in cells are antagonized biochemically by insoluble and stiff salts such as calcium oxalate which causes cell death. As such, mutation burden is connected with animal and human lifecycle. Previously published data corroborate such a model.