Environmental Lead Exposure is Associated with Higher Predicted 10-year Atherosclerotic Cardiovascular Disease Risk in Chinese Middle-aged and Older Adults
التفاصيل البيبلوغرافية
العنوان:
Environmental Lead Exposure is Associated with Higher Predicted 10-year Atherosclerotic Cardiovascular Disease Risk in Chinese Middle-aged and Older Adults
Background Environmental lead exposure has been connected with an increased risk of cardiovascular disease (CVD). Nonetheless, little is known about its impact on atherosclerotic cardiovascular disease (ASCVD). Methods To investigate the relationship between environmental lead exposure and the 10-year ASCVD risk in Chinese middle-aged and older adults, we conducted a cross-sectional study in rural areas of southern China in 2019–2020. We used the face-to-face questionnaire survey and physical examination to collect data and measured blood lead by ICP-MS. The 10-year ASCVD risk score was calculated through the Prediction for ASCVD Risk in China (China-PAR) equation model, and classified into low-risk (P P = 0.038) for the grade of 10-year ASCVD risk, compared with subjects in Q1. Subgroup analyses showed that the OR was higher in subjects those were males, below 60 years old, current smokers, and with hypertension. Conclusions Our study pointed out a nonlinear relationship between environmental lead exposure and 10-year ASCVD risk categories, highlighting the importance of controlling environmental lead exposure to prevent ASCVD, especially in susceptible populations.