Correction to: Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures
| العنوان: | Correction to: Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures |
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| المؤلفون: | Mones M AbuShady, Mahmoud M. Masoud, Walaa Alshasrany Abu Elhamed, Ali Abd Elaziz, Eman R. Youness, Fayez K Foudaa, Marwa Elhady, Maysa Samir Nassar |
| المصدر: | Child's Nervous System. 37:3283-3283 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Disease, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Ubiquitin, Internal medicine, medicine, Epilepsy surgery, biology, Glial fibrillary acidic protein, business.industry, Case-control study, General Medicine, medicine.disease, Ubiquitin carboxy-terminal hydrolase L1, 030104 developmental biology, Endocrinology, nervous system, Pediatrics, Perinatology and Child Health, biology.protein, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery |
| الوصف: | Epilepsy is a common neurological disease that has a negative impact on physical, social, and cognitive function. Seizure-induced neuronal injury is one of the suggested mechanisms of epilepsy complications. We aimed to evaluate the circulating level of glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) as markers of neuronal damage in children with epilepsy and its relation to epilepsy characteristics. This case control study included 30 children with epilepsy and 30 healthy children as a control group. Seizure severity was determined based on Chalfont score. Serum level of GFAP and UCH-L1were measured, and their associations with epilepsy characteristics were investigated. Circulating levels of GFAP and UCH-L1 were significantly higher in children with epilepsy than in controls (17.440 ± 6.74 and 5.700 ± 1.64 vs 7.06 ± 3.30 and 1.81 ± 0.23, respectively) especially in those with generalized and active seizures. GFAP and UCH-L1 were significantly correlated to the severity of seizures in the previous 6 months. Elevated GFAP level was a predictor for active seizures (OR 1.841, 95%CI 1.043–3.250, P = 0.035). Circulating GFAP and UCH-L1 expression is increased in children with epilepsy especially those with active seizures. GFAP and UCH-L 1may serve as peripheral biomarkers for neuronal damage in children with epilepsy that can be used to monitor disease progression and severity for early identification of those with drug-resistant epilepsy and those who are in need for epilepsy surgery. |
| تدمد: | 1433-0350 0256-7040 |
| DOI: | 10.1007/s00381-021-05136-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9b44e38ad8921d1775ab01c674fd66ce https://doi.org/10.1007/s00381-021-05136-5 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........9b44e38ad8921d1775ab01c674fd66ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14330350 02567040 |
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| DOI: | 10.1007/s00381-021-05136-5 |