Association of Standardized Uptake Values of Primary Breast Cancer on [18F]FDG PET/CT With Immunohistochemistry and Molecular Subtypes
| العنوان: | Association of Standardized Uptake Values of Primary Breast Cancer on [18F]FDG PET/CT With Immunohistochemistry and Molecular Subtypes |
|---|---|
| المؤلفون: | Nishita Goyal, Periakaruppan Gokulakrishnan, Arunan Murali, Leena Joseph Dennis, Rajeswaran Rangasami, Bhawna Dev |
| المصدر: | Archives of Breast Cancer. :175-186 |
| بيانات النشر: | Archives of Breast Cancer, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Medicine |
| الوصف: | Background: The prognostic factors for breast cancer include pretreatment staging, nodal and distant metastasis, hormone receptor status, ki67 index, and molecular subtype. For adequate treatment, [18F]FDG PET/CT is now being used to prognosticate the course and response of treatment in breast cancer patients. Our study aims to find the association between the metabolic activity of primary breast tumors as PET/CT SUV uptake and prognostic factors such as ER/PgR/Her2neu receptor status, molecular subtypes, ki67 labeling index, and nodal/distant metastasis. Methods: A retrospective observational study at our tertiary care institute included 228 breast cancer patients from March 2017 to April 2021. Pretreatment PET/CT imaging was done. The immunohistochemical analysis was performed on a biopsy/surgical specimen to determine the molecular subtype of breast cancer. Further, statistical analysis was performed to find the association between PET/CT findings with immunohistochemistry and thus, molecular subtypes of breast cancers. Results: Significantly higher SUV max was seen in tumors with ER-negative (Mean SUVmax-11.6; P-value=0.002), PgR negative (Mean SUVmax-11.1; p value-0.0005), triple-negative receptor status (Mean SUVmax-13.7; P-value=0.004) and high Ki67 index (P-value= |
| تدمد: | 2383-0433 2383-0425 |
| DOI: | 10.32768/abc.2023102175-186 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9b3b3d120020409c3cc8c4f9ca9e746f https://doi.org/10.32768/abc.2023102175-186 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........9b3b3d120020409c3cc8c4f9ca9e746f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23830433 23830425 |
|---|---|
| DOI: | 10.32768/abc.2023102175-186 |