The two-way route between delirium disorder and dementia: insights from Covid-19
| العنوان: | The two-way route between delirium disorder and dementia: insights from Covid-19 |
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| المؤلفون: | Giulia Bommarito, Valentina Garibotto, Giovanni B Frisoni, Frédéric Assal, Patrice H Lalive, Gilles Allali |
| المصدر: | Neurodegenerative Diseases. |
| بيانات النشر: | S. Karger AG, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Neurology, Neurology (clinical) |
| الوصف: | Background. Delirium disorder is a frequent neurological complication of SARS-CoV-2 infection and associated with an increased disease severity and mortality. Cognitive impairment is a major risk factor for developing delirium disorder during Covid-19, which, in turn, increases the risk of subsequent neurological complications and cognitive decline. Summary. The bidirectional connection between delirium disorder and dementia likely resides at multiple levels, and its pathophysiological mechanisms during Covid-19 include endothelial damage, blood-brain barrier dysfunction and local inflammation, with activation of microglia and astrocytes. Here, we describe the putative pathogenic pathways underlying delirium disorder during Covid-19 and highlight how they cross with the ones leading to neurodegenerative dementia. Key messages. The analysis of the two-sided link can offer useful insights for confronting with long-term neurological consequences of Covid-19 and framing future prevention and early treatment strategies. |
| تدمد: | 1660-2862 1660-2854 |
| DOI: | 10.1159/000530566 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9b0423391c453bc2131951161a5f6739 https://doi.org/10.1159/000530566 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........9b0423391c453bc2131951161a5f6739 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16602862 16602854 |
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| DOI: | 10.1159/000530566 |