Developmental and Condition-Related Changes in the Prefrontal Cortex Activity during Rest
| العنوان: | Developmental and Condition-Related Changes in the Prefrontal Cortex Activity during Rest |
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| المؤلفون: | Patricia A. Shewokis, Ling-Yin Liang, Nancy Getchell, Jia-Jin Jason Chen |
| المصدر: | Journal of Behavioral and Brain Science. :485-497 |
| بيانات النشر: | Scientific Research Publishing, Inc., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, Resting state fMRI, Brain activity and meditation, 05 social sciences, Cognition, Audiology, 050105 experimental psychology, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Age groups, medicine, 0501 psychology and cognitive sciences, Psychology, Prefrontal cortex, Eyes open, 030217 neurology & neurosurgery |
| الوصف: | The prefrontal cortex (PFC) plays an important role in cognitive process related to executive function, but is also active during resting states. Quantifying prefrontal cortex activity during resting states provides a baseline for interpreting task-induced brain activity. Researchers commonly use resting conditions where participants are prompted to stare at a screen (eyes open) or close their eyes (eyes closed). Are these two conditions equivalent representations of a baseline resting state? Further, does prefrontal cortex activity during these conditions change as a function of development? The aim of this study was to examine differences in prefrontal cortex activity between eyes open and eyes closed conditions during resting states in children and adults to provide a rationale of proper selection of baseline condition in future research. Thirty-six participants in 3 age groups were recruited in this study including twenty-four adults, five 12 - 15 years old children, and seven 8 - 11 years old children. Relative changes in concentrations of oxygenated hemoglobin (Δoxy-Hb) and deoxygenated hemoglobin (Δdeoxy-Hb) were obtained by using functional Near-Infrared Spectroscopy (fNIRS) in eyes closed (EC) and eyes open (EO) conditions, 3 minutes each. Contrasts were tested to compare the differences of Δoxy-Hb and Δdeoxy-Hb between eyes open and eyes closed conditions. The EC condition had significantly higher Δoxy-Hb than EO when all groups were combined (t (17.268) = 3.021, p = .008, Cohen’s d = –0.72). When comparing Δoxy-Hb between eyes conditions within each group, the younger group had significantly higher Δoxy-Hb in EC than EO (t (9.459) = 2.734, p = 0.022, Cohen’s d = –1.46). Based on these results, the EO condition may be a better baseline condition, particularly in studies with younger children, since it has less activity in the PFC that could interfere with interpretations of task-induced activity. |
| تدمد: | 2160-5874 2160-5866 |
| DOI: | 10.4236/jbbs.2016.612044 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::99dc67b6d32a83f53a79e0ff27b1e96d https://doi.org/10.4236/jbbs.2016.612044 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........99dc67b6d32a83f53a79e0ff27b1e96d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21605874 21605866 |
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| DOI: | 10.4236/jbbs.2016.612044 |