Social skills and autism spectrum disorder symptoms in children with neurofibromatosis type 1: evidence for clinical trial outcomes
| العنوان: | Social skills and autism spectrum disorder symptoms in children with neurofibromatosis type 1: evidence for clinical trial outcomes |
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| المؤلفون: | Kristina M Haebich, Christina L. Casnar, Anita K. Chisholm, Natalie A. Pride, Jonathan M. Payne, Danielle M Glad, Alice Maier, Kathryn N. North, Jennifer Lorenzo, Allison del Castillo, Karin S. Walsh, Melissa Rouel, Bonita P. Klein-Tasman |
| المصدر: | Developmental Medicine & Child Neurology. 62:813-819 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 030506 rehabilitation, education.field_of_study, Referral, Cross-sectional study, business.industry, Population, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Developmental Neuroscience, Social skills, Autism spectrum disorder, Rating scale, Pediatrics, Perinatology and Child Health, medicine, Clinical endpoint, Autism, Neurology (clinical), 0305 other medical science, education, business, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | AIM: We examined key features of two outcome measures for social dysfunction and autism spectrum disorder traits, the Social Responsiveness Scale, Second Edition (SRS-2) and the Social Skills Improvement System - Rating Scales (SSIS-RS), in children with neurofibromatosis type 1 (NF1). The aim of the study was to provide objective evidence as to which behavioural endpoint should be used in clinical trials. METHOD: Cross-sectional behavioural and demographic data were pooled from four paediatric NF1 tertiary referral centres in Australia and the United States (N=122; 65 males, 57 females; mean age [SD] 9y 2mo [3y], range 3-15y). RESULTS: Distributions of SRS-2 and SSIS-RS scores were unimodal and both yielded deficits, with a higher proportion of severely impaired scores on the SRS-2 (16.4%) compared to the SSIS-RS (8.2%). Pearson's product-moment correlations revealed that both questionnaires were highly related to each other (r=-0.72, p |
| تدمد: | 1469-8749 0012-1622 |
| DOI: | 10.1111/dmcn.14517 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::99d14d08200b9b2913b32db2f2998458 https://doi.org/10.1111/dmcn.14517 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........99d14d08200b9b2913b32db2f2998458 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14698749 00121622 |
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| DOI: | 10.1111/dmcn.14517 |