Systematic transcriptome analysis associated with physiological and chronological aging inCaenorhabditis elegans
| العنوان: | Systematic transcriptome analysis associated with physiological and chronological aging inCaenorhabditis elegans |
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| المؤلفون: | Seokjin Ham, Sieun S. Kim, Sangsoon Park, Eun Ji E. Kim, Sujeong Kwon, Hae-Eun H. Park, Yoonji Jung, Seung-Jae V. Lee |
| المصدر: | Genome Research. 32:2003-2014 |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Genetics, Genetics (clinical) |
| الوصف: | Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between chronological and physiological ages at the transcriptomic level has been a challenge because of its complexity. We analyzed the transcriptomic features associated with physiological and chronological aging usingCaenorhabditis elegansas a model. Many structural and functional transcript elements, such as noncoding RNAs and intron-derived transcripts, were up-regulated with chronological aging. In contrast, mRNAs with many biological functions, including RNA processing, were down-regulated with physiological aging. We also identified an age-dependent increase in the usage of distal 3′ splice sites in mRNA transcripts as a biomarker of physiological aging. Our study provides crucial information for dissecting chronological and physiological aging at the transcriptomic level. |
| تدمد: | 1549-5469 1088-9051 |
| DOI: | 10.1101/gr.276515.121 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::978f7c03019bb9a5abfb744515cae6df https://doi.org/10.1101/gr.276515.121 |
| رقم الانضمام: | edsair.doi...........978f7c03019bb9a5abfb744515cae6df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15495469 10889051 |
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| DOI: | 10.1101/gr.276515.121 |