Marine sponges play important roles in maintaining a stable marine microenvironment by factor of their symbiosis with other organisms. These ecological roles are indispensable. They are source of numerous bioactive compounds of therapeutics and biotechnology importance, revolutionizing research in these sectors at great depth. In this chapter, we highlighted the perspectives in research limitations, constraints, and global response towards marine sponge research and conservation. We examine the challenges faced by scientists in their quest to explore the ecological roles played by these ubiquitous benthos metazoans in marine ecosystems.