Pathologic basis of coronavirus disease 2019 (COVID-19) – An overview of cellular affinities, pathogenesis, clinical manifestations, autopsy findings and sequelae

التفاصيل البيبلوغرافية
العنوان: Pathologic basis of coronavirus disease 2019 (COVID-19) – An overview of cellular affinities, pathogenesis, clinical manifestations, autopsy findings and sequelae
المؤلفون: J.A. Atata, Collins Chimezie Udechukwu, Kelvin Olutimilehin Jolayemi, Ngozi Ejum Ogbuagu, Bala Ningi Umar, Juwon Pius Erin, Magdalene Ogbonneya Okoronkwo, Talatu Patience Markus, Ochuko Orakpoghenor, Olushola Samuel Olaolu
المصدر: Annals of Cytology and Pathology. :078-083
بيانات النشر: Peertechz Publications Private Limited, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Coronavirus disease 2019 (COVID-19), business.industry, Autopsy, Disease, medicine.disease, Bioinformatics, Pathogenesis, Respiratory failure, Paralysis, medicine, General Earth and Planetary Sciences, medicine.symptom, Cytokine storm, business, Collapse (medical), General Environmental Science
الوصف: The global terror instigated by coronavirus disease 2019 (COVID-19) cannot be underestimated and the need for drastic measures towards its control cannot be overemphasized. Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following attachment of the virus to specific receptors in the body. The distribution of these specialized receptors in various organs and tissues of the body is responsible for the various clinical presentations associated with the disease after infection. Despite the higher risk of spread of the infection, autopsies have been carried out though with maximum precautionary measures and information provided to further elucidate the extent of damages caused by the disease. Pathologic mechanisms leading to death from COVID-19 include respiratory failure due to surfactant deficiency and consequent alveolar collapse, cardiac syncope from direct damage to cardiac muscles, peripheral paralysis, cytokine storm and excessive haemorrhage from impaired coagulation. In patients that recover, potential outcomes which could be short- and/or long-term have been recognized. As a means to develop effective control, eradication and prevention strategies, a proper understanding of the mechanisms of SARS-CoV-2 infection will fully ensure a positive breakthrough. Hence, in this article, the pathologic basis of COVID-19 are provided based on extensive literature searches, and proposed mechanisms of pathogenesis, clinical manifestations, autopsy findings and sequelae are being described.
تدمد: 2640-7809
DOI: 10.17352/acp.000021
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9652f0891ae080b99ef33f3ed2079fba
https://doi.org/10.17352/acp.000021
Rights: OPEN
رقم الانضمام: edsair.doi...........9652f0891ae080b99ef33f3ed2079fba
قاعدة البيانات: OpenAIRE
الوصف
تدمد:26407809
DOI:10.17352/acp.000021