Synthesis of 2-Aryl-2,3-dihydro-3-sulfanyl-1H-isoindol-1-ones by Pummerer-Type Cyclization of N-Aryl-2-(sulfinylmethyl)benzamides

التفاصيل البيبلوغرافية
العنوان: Synthesis of 2-Aryl-2,3-dihydro-3-sulfanyl-1H-isoindol-1-ones by Pummerer-Type Cyclization of N-Aryl-2-(sulfinylmethyl)benzamides
المؤلفون: Hisatoshi Konishi, Hiroo Hashimoto, Kazuhiro Kobayashi, Teruhiko Suzuki
المصدر: Helvetica Chimica Acta. 94:2002-2009
بيانات النشر: Wiley, 2011.
سنة النشر: 2011
مصطلحات موضوعية: Aryl, Pummerer rearrangement, Organic Chemistry, Biochemistry, Medicinal chemistry, Catalysis, Benzoates, Inorganic Chemistry, chemistry.chemical_compound, Carbenium ion, chemistry, Sulfanyl, Drug Discovery, Physical and Theoretical Chemistry
الوصف: An efficient method for the synthesis of 2-aryl-2,3-dihydro-3-sulfanyl-1H-isoindol-1-ones 1via Pummerer-type cyclization of N-aryl-2-(sulfinylmethyl)benzamides 2 is described. Thus, treatment of these sulfinyl-benzamides 2, easily prepared from 2-(bromomethyl)benzoates 3 in three steps, with Ac2O at ca. 100° resulted in the formation of the desired isoindolones 1 in generally good yields.
تدمد: 0018-019X
DOI: 10.1002/hlca.201100204
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::93367dedc274fcf3533ce602e435fc25
https://doi.org/10.1002/hlca.201100204
Rights: CLOSED
رقم الانضمام: edsair.doi...........93367dedc274fcf3533ce602e435fc25
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0018019X
DOI:10.1002/hlca.201100204