ESMS and NMR investigations on the interaction of the anticancer drug cisplatin and chemopreventive agent selenomethionine †
| العنوان: | ESMS and NMR investigations on the interaction of the anticancer drug cisplatin and chemopreventive agent selenomethionine † |
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| المؤلفون: | Yuhua Mei, Xiao-Kang Ke, Longgen Zhu, Qin Liu, Zijian Guo, Junyong Zhang |
| المصدر: | Journal of the Chemical Society, Dalton Transactions. :911-916 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Cisplatin, Electrospray, Stereochemistry, Chemistry, chemistry.chemical_element, General Chemistry, Nuclear magnetic resonance spectroscopy, Reaction intermediate, Mass spectrometry, Adduct, medicine, Platinum, Selenium, medicine.drug |
| الوصف: | The reactions of L-selenomethionine (L-Se-MetH) with cisplatin, cis-[PtCl2(NH3)2], were investigated using electrospray mass spectroscopy (ESMS) and 2-D [1H–15N] NMR spectroscopy. The reaction intermediates and products identified were cis-[PtCl(L-Se-MetH)(NH3)2]+, cis-[Pt(L-Se-Met)(NH3)2]+, [PtCl(L-Se-MetH)(NH3)]+ and [Pt(L-Se-Met)(L-Se-MetH)]+. Some binuclear adducts were also detected by ESMS during the reaction, although they existed in minor amounts. Similar reactions with L-MetH were also conducted under similar conditions for comparison. This work provides the first detailed studies on the reaction of a platinum-based drug with L-Se-MetH. |
| تدمد: | 1364-5447 1472-7773 |
| DOI: | 10.1039/b008611h |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9302f52284e16126036bb90aa4fd9447 https://doi.org/10.1039/b008611h |
| رقم الانضمام: | edsair.doi...........9302f52284e16126036bb90aa4fd9447 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13645447 14727773 |
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| DOI: | 10.1039/b008611h |