P.172 Diffusion MRI characteristics change in select cerebral white matter tracts after decompressive surgery for degenerative cervical myelopathy
| العنوان: | P.172 Diffusion MRI characteristics change in select cerebral white matter tracts after decompressive surgery for degenerative cervical myelopathy |
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| المؤلفون: | AC Friesen, SA Detombe, P Doyle-Pettypiece, H Haddad, W Ng, K Gurr, C Bailey, P Rasoulinejad, F Siddiqi, R Bartha, N Duggal |
| المصدر: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 48:S69-S69 |
| بيانات النشر: | Cambridge University Press (CUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | nervous system, Neurology, Neurology (clinical), General Medicine |
| الوصف: | Background: Degenerative cervical myelopathy is characterized by progressive compression of the spinal cord resulting in debilitating loss of dexterity, independent ambulation, and sphincter control. Diffusion tensor imaging (DTI) has shown that, compared to healthy controls, myelopathy patients have decreased integrity of the corticospinal tracts and corpus callosum (Bernabeu-Sanz et al, 2020). Methods: Twenty-six myelopathy patients consented to cerebral diffusion tensor imaging (3 Tesla, 32 directions, b=1000) preoperatively, as well as 6-weeks, 12-weeks, and 6-months postoperatively. Average mean diffusivity (MD), fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD) were measured in the corticospinal tracts, forceps major, and forceps minor. Results: Both MD and RD decreased from 6-12 weeks postoperatively in the right corticospinal tract. The forceps major of the corpus callosum showed an initial postoperative increase in MD followed by a subsequent increase in FA and decrease in RD 3-6 months postoperatively. The AD of the forceps major increased both immediately and 3-6 months postoperatively. Conclusions: Changes in microstructural integrity of the corticospinal tract and forceps major over the postoperative recovery period suggest a pattern of recovery in myelopathy patients. This study is the first to report postoperative DTI changes in myelopathy-relevant white matter tracts in the brain. |
| تدمد: | 2057-0155 0317-1671 |
| DOI: | 10.1017/cjn.2021.448 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9011dccd6bfcdcd517f96f580d89e9fa https://doi.org/10.1017/cjn.2021.448 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........9011dccd6bfcdcd517f96f580d89e9fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20570155 03171671 |
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| DOI: | 10.1017/cjn.2021.448 |