Abstract P6-16-01: Refined local recurrence risk estimates based on a multigene expression assay combined with clinicopathological features significantly impacts radiotherapy recommendation in patients with low/intermediate risk DCIS treated with breast-conserving surgery
| العنوان: | Abstract P6-16-01: Refined local recurrence risk estimates based on a multigene expression assay combined with clinicopathological features significantly impacts radiotherapy recommendation in patients with low/intermediate risk DCIS treated with breast-conserving surgery |
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| المؤلفون: | Christiaan Stevens, Margaret Anthes, Sally L. Smith, Eileen Rakovitch, Hany Soliman, Ericka Wiebe, Timothy J. Whelan, Francisco Perera, Senti Senthelal, Jeffrey Q. Cao, Mira Goldberg, Luciana Spadafora, Iwa Kong, Laval Grimard, Anne Koch, Sameer Parpia |
| المصدر: | Cancer Research. 80:P6-16 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, business.industry, medicine.medical_treatment, Recurrence risk, Radiation therapy, Multigene expression, Internal medicine, medicine, Breast-conserving surgery, Clinicopathological features, In patient, business, Intermediate risk |
| الوصف: | Background: Guidelines recommend that breast radiation (RT) can be omitted for patients with a low risk of local recurrence (LR) after breast-conserving surgery (BCS) for DCIS. The inability to identify women at low risk of LR ( Methods: Prospective cohort study of women with low/moderate risk pure DCIS treated with BCS. Cases with age 2.5cm, multifocality, or prior breast cancer were excluded. Baseline CPFs, the DS and risk of LR were collected. Pre-assay, the radiation oncologist provided an estimate of 10-year LR risk without RT and a preliminary recommendation for RT. Post-assay, final recommendations were recorded. The primary outcome was change in treatment recommendation by the radiation oncologist. Target sample size was 220 to provide data on 200 evaluable patients with adequate precision. Results: 217 patients were evaluable: mean age, 63 years and mean tumor size, 1.1 cm. Nuclear grade was low in 26 (12%), intermediate in 116 (53%), and high in 75 (35%) of patients. Mean DS = 32; 140 (64%) low (15% in 128 (59%) cases. Post-assay, estimated 10-yr LR risk after BCS was 15% in 49 (22%) (RT recommended in 98%). Conclusion: The use of the DCIS Score combined with CPFs identifies more women with an estimated low ( Table 1.Post-assay 10-yr LR risk15%(N=101)(N= 67)(N=49)Pre-assay estimated 10-yr LR risk• 15% (N=128)424739RT recommended• Yes17 (17%)44 (66%)48 (98%)• No83 (83%)23 (34%)1 (2%) Citation Format: Eileen Rakovitch, Anne Koch, Laval Grimard, Hany Soliman, Christiaan Stevens, Francisco Perera, Iwa Kong, Senti Senthelal, Margaret Anthes, Ericka Wiebe, Jeffrey Cao, Mira Goldberg, Sally Smith, Luciana Spadafora, Sameer Parpia, Timothy Whelan. Refined local recurrence risk estimates based on a multigene expression assay combined with clinicopathological features significantly impacts radiotherapy recommendation in patients with low/intermediate risk DCIS treated with breast-conserving surgery [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P6-16-01. |
| تدمد: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.sabcs19-p6-16-01 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8f54e4fce9a0f331dbb10b473f3bbd47 https://doi.org/10.1158/1538-7445.sabcs19-p6-16-01 |
| رقم الانضمام: | edsair.doi...........8f54e4fce9a0f331dbb10b473f3bbd47 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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| DOI: | 10.1158/1538-7445.sabcs19-p6-16-01 |