New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids
| العنوان: | New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids |
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| المؤلفون: | Ya. A. Ivanenkov, Sergey V. Kovalev, Elena K. Beloglazkina, E. Yu. Yamansarov, Natalia L. Klyachko, Nikolai V. Zyk, Rostislav A Petrov, Dmitry A. Skvortsov, Sergei A Evteev, Anton V Lopukhov, Alexander G. Majouga |
| المصدر: | Russian Chemical Bulletin. 68:2331-2338 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Betulin, 010405 organic chemistry, Chemistry, Stereochemistry, In silico, General Chemistry, 010402 general chemistry, 01 natural sciences, In vitro, 0104 chemical sciences, Terpene, chemistry.chemical_compound, Triterpenoid, Betulinic acid, Surface plasmon resonance spectroscopy, Conjugate |
| الوصف: | New ligands for targeted delivery to the liver based on glycoconjugated natural triterpenoids are proposed. Simple chemical transformations of starting lupane triterpenes led to betulin or betulinic acid conjugates with N-acetyl-d-galactosamine linked through an isopropenyl fragment of the terpene skeleton. The obtained compounds were non-toxic in vitro to a series of cancer cell lines and normal cells. Molecular docking in silico and surface plasmon resonance spectroscopy revealed a high specificity of the synthesized glycotriterpenoids to the asialogly-coprotein receptor of hepatocytes. |
| تدمد: | 1573-9171 1066-5285 |
| DOI: | 10.1007/s11172-019-2707-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8e6f153ec852abc74a9c23a071b5973f https://doi.org/10.1007/s11172-019-2707-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........8e6f153ec852abc74a9c23a071b5973f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15739171 10665285 |
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| DOI: | 10.1007/s11172-019-2707-9 |