التفاصيل البيبلوغرافية
| العنوان: |
Protective Effects of 10% Ethanolic Extract from Capsosiphon fulvescens against Ethanol-induced Oxidative Stress |
| المؤلفون: |
Cho, Haneul, You, Yanghee, Park, Jeongjin, Kim, Soo-Il, Jun, Woojin |
| بيانات النشر: |
Journal of International Society of Antioxidants in Nutrition & Health, 2016. |
| سنة النشر: |
2016 |
| الوصف: |
The consumption of alcohol, especially in the long-term, has the potential adverse effects that include development of alcohol-related liver disease. Oxidative stress is considered as one of the key mechanisms responsible for alcoholic liver damage. In the present study, the protective effects of 10% ethanolic extract (CF) from Capsosiphon fulvescens against ethanol-induced hepatotoxicity was investigated in HepG2 cells transfected with human CYP2E1 (HepG2/2E1). The oxidative stress induced by ethanol caused a drastic decrease in cell viability with approximately 60%. This ethanol-induced cellular toxicity, however, was significantly reduced when the HepG2/2E1 cells were pretreated with CF. Hepatoprotective effects of CF against alcoholic damage were confirmed in male C57BL/6 mice. Mice (n=8 per group), which received CF (900 mg/kg b.w./day) with ethanol revealed the prevention of alcohol-induced hepatotoxicity as evidenced by the significant reductions of serum alanine and aspartate aminotransferase activities compared to ethanol-alone administered mice (5 g/kg b.w./day of ethanol). Furthermore, CF enhanced antioxidant capacities with higher activities of SOD, catalase, glutathione-S-transferase, glutathione reductase, and glutathione peroxidase, and level of reduced glutathione. These results suggest that CF could be a candidate used for the prevention against various liver diseases induced by oxidative stress via elevating antioxidative potentials.
Journal of International Society of Antioxidants in Nutrition & Health, Vol 3, No 3 (2016) |
| اللغة: |
English |
| DOI: |
10.18143/jisanh_v3i3_1206 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::8cce2ce74fb5017f665fe03f5162d9e4 |
| رقم الانضمام: |
edsair.doi...........8cce2ce74fb5017f665fe03f5162d9e4 |
| قاعدة البيانات: |
OpenAIRE |