ChemInform Abstract: Regiospecific Synthesis of 6-Alkyltropan-2-ones
| العنوان: | ChemInform Abstract: Regiospecific Synthesis of 6-Alkyltropan-2-ones |
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| المؤلفون: | Mark L. Trudell, Amy L. Bradley, Naijue Zhu, Cheryl L. Klein, Stacey A. Lomenzo |
| المصدر: | ChemInform. 29 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | chemistry.chemical_compound, chemistry, Stereochemistry, Diastereomer, Tropane, General Medicine, Alkylation, Ring (chemistry) |
| الوصف: | A new synthetic approach for the regiospecific alkylation of the 6-position of the tropane ring system has been developed. Alkylation, desulfonylation and deprotection of tropanes 5 and 12 furnished a series of 6-endo-alkyltropan-2-one derivatives 8a-e, 15a-e and 16a-e (R = Me, Et, n-Pr, n-Bu, Bn) stereoselectively in good yields. The 6-endo isomers 15a-e and 6-exo isomers 16a-e were easily obtained as pure diastereoisomers. |
| تدمد: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.199804213 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8ae67aa53b6e05323dffe9a707594bdc https://doi.org/10.1002/chin.199804213 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........8ae67aa53b6e05323dffe9a707594bdc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222667 09317597 |
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| DOI: | 10.1002/chin.199804213 |