Invulnerability of bromelain against oxidative degeneration and cholinergic deficits imposed by dichlorvos in mice brains
| العنوان: | Invulnerability of bromelain against oxidative degeneration and cholinergic deficits imposed by dichlorvos in mice brains |
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| المؤلفون: | Sonam Agarwal, Bharti Chaudhary, Renu Bist |
| المصدر: | Frontiers in Biology. 13:56-62 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Ecology, Bromelain (pharmacology), Thiobarbituric acid, Oxidative phosphorylation, Pharmacology, Biology, medicine.disease_cause, Neuroprotection, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Dichlorvos, Genetics, medicine, TBARS, Cholinergic, 030217 neurology & neurosurgery, Ecology, Evolution, Behavior and Systematics, Oxidative stress, Biotechnology |
| الوصف: | The present study elucidates the protective potential of bromelain against dichlorvos intoxication in mice brains. Dichlorvos induces the oxidative stress by disproportionating the balance between free radicals generation and their scavenging in neurons which leads to neuronal degeneration. In this study, mice were divided into four groups-group I (control), group II (dichlorvos treated), group III (bromelain treated) and group IV (exposed to both bromelain and dichlorvos both). Dichlorvos treatment increased the levels of thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC) which indicate the increased oxidative stress. Meanwhile, brain endogenous antioxidants and cholinesterases level was decreased after dichlorvos exposure. Levels of TBARS and PCC decreased whereas cholinesterases level was recorded to be elevated after bromelain exposure. Bromelain offered neuroprotection by decreasing oxidative stress and augmenting cholinesterases in mice brains. This study highlights the invulnerability of bromelain against oxidative and cholinergic deficits in mice brains. |
| تدمد: | 1674-7992 1674-7984 |
| DOI: | 10.1007/s11515-018-1479-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8a07543d7ac8248085f95ba25482c24e https://doi.org/10.1007/s11515-018-1479-1 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........8a07543d7ac8248085f95ba25482c24e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16747992 16747984 |
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| DOI: | 10.1007/s11515-018-1479-1 |