RETRACTED ARTICLE: TWO MIXED-LIGAND Cu(II) COORDINATION POLYMERS: PROTECTIVE EFFECT ON SEPSIS BY REDUCING AN EXCESSIVE INFLAMMATORY RESPONSE
| العنوان: | RETRACTED ARTICLE: TWO MIXED-LIGAND Cu(II) COORDINATION POLYMERS: PROTECTIVE EFFECT ON SEPSIS BY REDUCING AN EXCESSIVE INFLAMMATORY RESPONSE |
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| المؤلفون: | B. Ren, Y. Fang, G. Q. Fu, E. L. Liu, X. F. Zan, J. J. Yao, M. J. Chen |
| المصدر: | Journal of Structural Chemistry. 62:810-816 |
| بيانات النشر: | Pleiades Publishing Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Biphenyl, chemistry.chemical_classification, Inflammatory response, Mixed ligand, Polymer, medicine.disease, Medicinal chemistry, Inorganic Chemistry, Sepsis, chemistry.chemical_compound, chemistry, In vivo, Materials Chemistry, medicine, Physical and Theoretical Chemistry, Benzene, Linker |
| الوصف: | By the reaction of a rigid π-conjugated H4L linker (5,5′-(1,3,6,8-tetraoxobenzo[lmn][3],[8]phenanthroline-2-7-diyl)bis-1,3-benzenedicarboxylic acid), Cu(NO3)2, and N-donor auxiliary linkers, two new Cu-based coordination polymers (CPs), namely {[Cu(L)0.5(1,4-bib)(H2O)2]·0.5H2O}n (1) and {[Cu(H2L)(4,4′-bibp)(H2O)2]}n (2) {1,4-bib = 1,4-bis(1-imidazolyl)benzene, 4,4′-bibp = 4,4′-bis(imidazolyl)biphenyl} are synthesized under solvothermal conditions and characterized. Furthermore, the protective effect of compounds 1 and 2 on the sepsis mice model is evaluated and the related mechanism is explored. Firstly, the CFU counting assay is performed to detect the bactericidal effect of compounds 1 and 2 in vivo. Then, the ELISA assay is conducted to measure the release of interleukin-1β (IL-1β) and interleukin-6 (IL-6) into the plasma after treatment with the compounds. |
| تدمد: | 1573-8779 0022-4766 |
| DOI: | 10.1134/s0022476621050176 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::89c3e756db1515b01f6bedd2cb5a8d97 https://doi.org/10.1134/s0022476621050176 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........89c3e756db1515b01f6bedd2cb5a8d97 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15738779 00224766 |
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| DOI: | 10.1134/s0022476621050176 |