Outcomes and Practice Preferences After Endophthalmitis Following Anti-VEGF Intravitreal Injection
| العنوان: | Outcomes and Practice Preferences After Endophthalmitis Following Anti-VEGF Intravitreal Injection |
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| المؤلفون: | Ryan J. Whitted, Tavé van Zyl, Kevin J. Blinder, Ananda Kalevar, Carl D. Regillo, John S. Pollack, Asheesh Tewari, Gaurav K. Shah, Lawrence J. Singerman, Abdallah Jeroudi, Jonathan Hu, Charles C. Wykoff, Dean Eliott, Mahdi Rostamizadeh, J. Michael Jumper, Anthony Joseph, Brett M. Weinstock, Musa Abdelaziz, Anthony P. Leonard, Marina Gilca, John W. Kitchens, Yicheng Chen, Vaishali Shah, Rui Wang, Bobeck S. Modjtahedi, Gregory D. Lee, Jeffrey S. Heier |
| المصدر: | Journal of VitreoRetinal Diseases. 3:411-419 |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Anti vegf, medicine.medical_specialty, business.industry, Growth factor, medicine.medical_treatment, Diabetic macular edema, Vitreoretinal surgery, medicine.disease, 03 medical and health sciences, Retinal neovascularization, 0302 clinical medicine, Endophthalmitis, Choroidal neovascularization, Central retinal vein occlusion, Ophthalmology, 030221 ophthalmology & optometry, medicine, 030212 general & internal medicine, medicine.symptom, business |
| الوصف: | Purpose:This study examines treatment-based outcomes of endophthalmitis due to antivascular endothelial growth factor (anti-VEGF) intravitreal injection and its effect on subsequent management of neovascular disease.Methods:A retrospective multicenter study was conducted of 157 patients with a diagnosis of endophthalmitis following anti-VEGF intravitreal injection at 10 major ophthalmic centers.Results:The median number of injections before endophthalmitis was 10 (range, 1 to 84 injections). Initial treatment with tap and inject with or without subsequent vitrectomy trended toward smaller visual acuity changes from baseline (4 ETDRS [Early Treatment Diabetic Retinopathy Study] letter difference vs 19 ETDRS letter difference) compared with initial vitrectomy, but the difference was not statistically significant. There was no significant change in medication choice among injections after endophthalmitis. There was a statistically significant shift away from regular interval (1- to 2-month) injections and a shift toward treat-and-extend and as-needed injection algorithms.Conclusions:The visual outcomes were not significantly different between patients who initially underwent tap and injection of antibiotics and those who underwent vitrectomy. There was no significant change in medication choice before and after endophthalmitis but there was a shift toward lower-frequency injection algorithms after postintravitreal injection endophthalmitis compared with prior. |
| تدمد: | 2474-1272 2474-1264 |
| DOI: | 10.1177/2474126419858492 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8788ea7b3e618ed6424abb2718e9c9b9 https://doi.org/10.1177/2474126419858492 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........8788ea7b3e618ed6424abb2718e9c9b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24741272 24741264 |
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| DOI: | 10.1177/2474126419858492 |