التفاصيل البيبلوغرافية
| العنوان: |
Modeling mechanical properties of polyhydroxyalkanoate during degradation in animal tissue |
| المؤلفون: |
M d.Fazlay Rabbi, Nicholas Bach, Vijaya Chalivendra, Abdulrahman A. Kehail, Christopher J. Brigham |
| المصدر: |
Polymers for Advanced Technologies. 28:1879-1883 |
| بيانات النشر: |
Wiley, 2017. |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
0301 basic medicine, chemistry.chemical_classification, Materials science, Polymers and Plastics, Enthalpy, Kinetics, HEK 293 cells, 02 engineering and technology, Polymer, 021001 nanoscience & nanotechnology, Polyhydroxyalkanoates, 03 medical and health sciences, 030104 developmental biology, Chemical engineering, chemistry, Polymer chemistry, Degradation (geology), Elongation, 0210 nano-technology, Dimensionless quantity |
| الوصف: |
Polyhydroxyalkanoates (PHAs) are a family of biodegradable and biocompatible polymers produced by several species microorganisms that possess favorable mechanical properties (e.g. strength and elongation properties). Different types of PHA polymers have been used in medical applications. However, in order to better understand the use of this polymer in the different applications, a thorough understanding of the kinetics of in vivo degradation is one of the major requirements. In this study, poly(3-hydroxybutyrate) (PHB) was subcutaneously implanted in mice and incubated for 2, 4, 8, or 16 weeks. After removal from the animal, the strength, elongation, mass loss, and enthalpy of the PHB were tested for each time point. From these data, a mathematical model was generated by Rayleigh's method of dimensional analysis, where polymer strength over tissue contact time could be predicted. To prove the model, previous data obtained by our group were used: poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(HB-co-HHx)] incubation in the presence of human embryonic kidney cells (HEK). It was found that the developed model was aligned with experimental results, could predict the strength of the polymer when in contact with cells, and the predicted strength follows the trend of the experimental data. Also, the dimensionless constant (K) value associated with the model is different for both experiments, where this constant, produced via experimental data, is used for construction of a homogeneous equation. Copyright © 2017 John Wiley & Sons, Ltd. |
| تدمد: |
1042-7147 |
| DOI: |
10.1002/pat.4076 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::873ddd304df794a57a6c51bb277edf94
https://doi.org/10.1002/pat.4076 |
| Rights: |
CLOSED |
| رقم الانضمام: |
edsair.doi...........873ddd304df794a57a6c51bb277edf94 |
| قاعدة البيانات: |
OpenAIRE |