The paper presents the results of a study on the structure and catalytic activity of MgF2 supported binary copper and manganese oxides, prepared using a co-impregnation procedure, contrasted to the data obtained for Cu/MgF2 and Mn/MgF2. The catalysts were characterised by means of BET, X-ray diffraction (XRD), temperature-programmed reduction (TPR) and infrared (IR) methods. The results proved the presence of CuMn2O4 type spinel structures in the mixed systems CuO and MnOx supported on MgF2, forming already at 400 °C. The activity of the mixed copper-manganese oxides and single metal oxides supported on MgF2 has been studied in the reactions of 2-propanol decomposition, cyclohexene dehydrogenation, oxidation of CO and reduction of NO by C3H6. The double oxide systems were found more effective than the catalysts obtained on the basis of individual oxides.