Reductions in alanine aminotransferase levels with liraglutide treatment are greatest in those with raised baseline levels and are independent of weight loss: real-world outcome data from the ABCD Nationwide Liraglutide Audit
| العنوان: | Reductions in alanine aminotransferase levels with liraglutide treatment are greatest in those with raised baseline levels and are independent of weight loss: real-world outcome data from the ABCD Nationwide Liraglutide Audit |
|---|---|
| المؤلفون: | Thomas SJ Crabtree, Susannah Rowles, Stephanie Tarpey, Adele Kennedy, John Chalmers, Rahul Nayar, Amanda Lee, Ken Darzy, Peter Winocour, John Lindsay, Iskandar Idris, Ken Y Thong, Piya Sen Gupta, Amar Puttanna, Pranav Kumar, Robert EJ Ryder, On Behalf of ABCD Nationwide Audit Contributors |
| المصدر: | British Journal of Diabetes. 19:118-123 |
| بيانات النشر: | ABCD Diabetes Care, Ltd., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | education.field_of_study, medicine.medical_specialty, Liraglutide, business.industry, Fatty liver, Population, Type 2 Diabetes Mellitus, General Medicine, Disease, medicine.disease, Gastroenterology, Clinical trial, Weight loss, Internal medicine, medicine, Clinical significance, medicine.symptom, business, education, medicine.drug |
| الوصف: | People with type 2 diabetes mellitus experience an increased prevalence of non-alcoholic fatty liver disease (NAFLD) compared with the general population and often with worse outcomes. As part of the ABCD Liraglutide Nationwide Audit Programme, we obtained and analysed data from 2009 to 2018 to assess the impact of liraglutide on alanine aminotransferase (ALT) levels as a marker of liver inflammation (often used in clinical trials as a marker of NAFLD). After excluding those with insufficient or incomplete data, we analysed the results from 1,759 patients treated in the real-world clinical setting. Our results demonstrated an overall significant decrease in median ALT (−1 U/L, 95% CI −1 to −2, p |
| تدمد: | 2397-6241 2397-6233 |
| DOI: | 10.15277/bjd.2019.227 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::86698fc49f7ca34ddca029b8202e527a https://doi.org/10.15277/bjd.2019.227 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........86698fc49f7ca34ddca029b8202e527a |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi...........86698fc49f7ca34ddca029b8202e527a 856 3 unknown 855.836364746094 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi...........86698fc49f7ca34ddca029b8202e527a&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_________::86698fc49f7ca34ddca029b8202e527a# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Reductions in alanine aminotransferase levels with liraglutide treatment are greatest in those with raised baseline levels and are independent of weight loss: real-world outcome data from the ABCD Nationwide Liraglutide Audit
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Thomas+SJ+Crabtree%22">Thomas SJ Crabtree</searchLink><br /><searchLink fieldCode="AR" term="%22Susannah+Rowles%22">Susannah Rowles</searchLink><br /><searchLink fieldCode="AR" term="%22Stephanie+Tarpey%22">Stephanie Tarpey</searchLink><br /><searchLink fieldCode="AR" term="%22Adele+Kennedy%22">Adele Kennedy</searchLink><br /><searchLink fieldCode="AR" term="%22John+Chalmers%22">John Chalmers</searchLink><br /><searchLink fieldCode="AR" term="%22Rahul+Nayar%22">Rahul Nayar</searchLink><br /><searchLink fieldCode="AR" term="%22Amanda+Lee%22">Amanda Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Ken+Darzy%22">Ken Darzy</searchLink><br /><searchLink fieldCode="AR" term="%22Peter+Winocour%22">Peter Winocour</searchLink><br /><searchLink fieldCode="AR" term="%22John+Lindsay%22">John Lindsay</searchLink><br /><searchLink fieldCode="AR" term="%22Iskandar+Idris%22">Iskandar Idris</searchLink><br /><searchLink fieldCode="AR" term="%22Ken+Y+Thong%22">Ken Y Thong</searchLink><br /><searchLink fieldCode="AR" term="%22Piya+Sen+Gupta%22">Piya Sen Gupta</searchLink><br /><searchLink fieldCode="AR" term="%22Amar+Puttanna%22">Amar Puttanna</searchLink><br /><searchLink fieldCode="AR" term="%22Pranav+Kumar%22">Pranav Kumar</searchLink><br /><searchLink fieldCode="AR" term="%22Robert+EJ+Ryder%22">Robert EJ Ryder</searchLink><br /><searchLink fieldCode="AR" term="%22On+Behalf+of+ABCD+Nationwide+Audit+Contributors%22">On Behalf of ABCD Nationwide Audit Contributors</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>British Journal of Diabetes</i>. 19:118-123 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => ABCD Diabetes Care, Ltd., 2019. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2019 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22education%2Efield%5Fof%5Fstudy%22">education.field_of_study</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Emedical%5Fspecialty%22">medicine.medical_specialty</searchLink><br /><searchLink fieldCode="DE" term="%22Liraglutide%22">Liraglutide</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22Fatty+liver%22">Fatty liver</searchLink><br /><searchLink fieldCode="DE" term="%22Population%22">Population</searchLink><br /><searchLink fieldCode="DE" term="%22Type+2+Diabetes+Mellitus%22">Type 2 Diabetes Mellitus</searchLink><br /><searchLink fieldCode="DE" term="%22General+Medicine%22">General Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Disease%22">Disease</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Gastroenterology%22">Gastroenterology</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trial%22">Clinical trial</searchLink><br /><searchLink fieldCode="DE" term="%22Weight+loss%22">Weight loss</searchLink><br /><searchLink fieldCode="DE" term="%22Internal+medicine%22">Internal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+significance%22">Clinical significance</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Esymptom%22">medicine.symptom</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22education%22">education</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edrug%22">medicine.drug</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => People with type 2 diabetes mellitus experience an increased prevalence of non-alcoholic fatty liver disease (NAFLD) compared with the general population and often with worse outcomes. As part of the ABCD Liraglutide Nationwide Audit Programme, we obtained and analysed data from 2009 to 2018 to assess the impact of liraglutide on alanine aminotransferase (ALT) levels as a marker of liver inflammation (often used in clinical trials as a marker of NAFLD). After excluding those with insufficient or incomplete data, we analysed the results from 1,759 patients treated in the real-world clinical setting. Our results demonstrated an overall significant decrease in median ALT (−1 U/L, 95% CI −1 to −2, p ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2397-6241<br />2397-6233 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.15277/bjd.2019.227 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_________::86698fc49f7ca34ddca029b8202e527a" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_________::86698fc49f7ca34ddca029b8202e527a</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.15277/bjd.2019.227" linkWindow="_blank">https://doi.org/10.15277/bjd.2019.227</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi...........86698fc49f7ca34ddca029b8202e527a ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.15277/bjd.2019.227
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 6
[StartPage] => 118
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => education.field_of_study
[Type] => general
)
[1] => Array
(
[SubjectFull] => medicine.medical_specialty
[Type] => general
)
[2] => Array
(
[SubjectFull] => Liraglutide
[Type] => general
)
[3] => Array
(
[SubjectFull] => business.industry
[Type] => general
)
[4] => Array
(
[SubjectFull] => Fatty liver
[Type] => general
)
[5] => Array
(
[SubjectFull] => Population
[Type] => general
)
[6] => Array
(
[SubjectFull] => Type 2 Diabetes Mellitus
[Type] => general
)
[7] => Array
(
[SubjectFull] => General Medicine
[Type] => general
)
[8] => Array
(
[SubjectFull] => Disease
[Type] => general
)
[9] => Array
(
[SubjectFull] => medicine.disease
[Type] => general
)
[10] => Array
(
[SubjectFull] => Gastroenterology
[Type] => general
)
[11] => Array
(
[SubjectFull] => Clinical trial
[Type] => general
)
[12] => Array
(
[SubjectFull] => Weight loss
[Type] => general
)
[13] => Array
(
[SubjectFull] => Internal medicine
[Type] => general
)
[14] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[15] => Array
(
[SubjectFull] => Clinical significance
[Type] => general
)
[16] => Array
(
[SubjectFull] => medicine.symptom
[Type] => general
)
[17] => Array
(
[SubjectFull] => business
[Type] => general
)
[18] => Array
(
[SubjectFull] => education
[Type] => general
)
[19] => Array
(
[SubjectFull] => medicine.drug
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Reductions in alanine aminotransferase levels with liraglutide treatment are greatest in those with raised baseline levels and are independent of weight loss: real-world outcome data from the ABCD Nationwide Liraglutide Audit
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Thomas SJ Crabtree
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Susannah Rowles
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Stephanie Tarpey
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Adele Kennedy
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => John Chalmers
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Rahul Nayar
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Amanda Lee
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ken Darzy
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Peter Winocour
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => John Lindsay
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Iskandar Idris
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ken Y Thong
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Piya Sen Gupta
)
)
)
[13] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Amar Puttanna
)
)
)
[14] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Pranav Kumar
)
)
)
[15] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Robert EJ Ryder
)
)
)
[16] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => On Behalf of ABCD Nationwide Audit Contributors
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 17
[M] => 12
[Type] => published
[Y] => 2019
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 23976241
)
[1] => Array
(
[Type] => issn-print
[Value] => 23976233
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[3] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 19
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => British Journal of Diabetes
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |