Reductions in alanine aminotransferase levels with liraglutide treatment are greatest in those with raised baseline levels and are independent of weight loss: real-world outcome data from the ABCD Nationwide Liraglutide Audit
| العنوان: | Reductions in alanine aminotransferase levels with liraglutide treatment are greatest in those with raised baseline levels and are independent of weight loss: real-world outcome data from the ABCD Nationwide Liraglutide Audit |
|---|---|
| المؤلفون: | Thomas SJ Crabtree, Susannah Rowles, Stephanie Tarpey, Adele Kennedy, John Chalmers, Rahul Nayar, Amanda Lee, Ken Darzy, Peter Winocour, John Lindsay, Iskandar Idris, Ken Y Thong, Piya Sen Gupta, Amar Puttanna, Pranav Kumar, Robert EJ Ryder, On Behalf of ABCD Nationwide Audit Contributors |
| المصدر: | British Journal of Diabetes. 19:118-123 |
| بيانات النشر: | ABCD Diabetes Care, Ltd., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | education.field_of_study, medicine.medical_specialty, Liraglutide, business.industry, Fatty liver, Population, Type 2 Diabetes Mellitus, General Medicine, Disease, medicine.disease, Gastroenterology, Clinical trial, Weight loss, Internal medicine, medicine, Clinical significance, medicine.symptom, business, education, medicine.drug |
| الوصف: | People with type 2 diabetes mellitus experience an increased prevalence of non-alcoholic fatty liver disease (NAFLD) compared with the general population and often with worse outcomes. As part of the ABCD Liraglutide Nationwide Audit Programme, we obtained and analysed data from 2009 to 2018 to assess the impact of liraglutide on alanine aminotransferase (ALT) levels as a marker of liver inflammation (often used in clinical trials as a marker of NAFLD). After excluding those with insufficient or incomplete data, we analysed the results from 1,759 patients treated in the real-world clinical setting. Our results demonstrated an overall significant decrease in median ALT (−1 U/L, 95% CI −1 to −2, p |
| تدمد: | 2397-6241 2397-6233 |
| DOI: | 10.15277/bjd.2019.227 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::86698fc49f7ca34ddca029b8202e527a https://doi.org/10.15277/bjd.2019.227 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........86698fc49f7ca34ddca029b8202e527a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23976241 23976233 |
|---|---|
| DOI: | 10.15277/bjd.2019.227 |