Anti-cancer effects of Vernonia amygdalina: A systematic review
| العنوان: | Anti-cancer effects of Vernonia amygdalina: A systematic review |
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| المؤلفون: | Nozlena Abdul Samad, Julia Joseph, Vuanghao Lim, Hemn Hassan Othman, Heshu Sulaiman Rahman |
| المصدر: | Tropical Journal of Pharmaceutical Research. 19:1775-1784 |
| بيانات النشر: | African Journals Online (AJOL), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Cell cycle checkpoint, biology, DNA synthesis, DNA damage, business.industry, Vernonia amygdalina, Pharmaceutical Science, Cancer, biology.organism_classification, medicine.disease, Apoptosis, Internal medicine, Cancer cell, medicine, Pharmacology (medical), Viability assay, business |
| الوصف: | Purpose: To systematically review all the studies that have addressed the anti-cancer activities of the VA leaf extract in vitro to determine the strength of evidence of its anti-cancer effects and whether it can be used as an effective cancer therapy.Methods: The databases of Scopus, Science Direct, PubMed, Springer, and Directory of Open Access Journals were searched for relevant articles. Only articles published in the English language from January 2000 to November 2018 were selected for full-text retrieval and review, before being included in the final review.Results: From a total of 28 articles identified for full-text retrieval, only 17 fulfilled the inclusion criteria. The papers reviewed showed that VA decreases cell viability, inhibits DNA synthesis and causes DNA damage in cancer cells. VA also induces apoptosis and cell cycle arrest in cancer cells via gene regulation. All in all, there is evidence showing that VA possesses time- and concentration-dependent anti-cancer activity.Conclusion: The VA leaf extract has the potential to be developed into cancer therapeutics. However, more research is needed on its effect on normal cells before VA is developed into a cancer therapeutic. Keywords: Vernonia amygdalina, Anti-cancer effect, DNA damage, Apoptosis |
| تدمد: | 1596-9827 1596-5996 |
| DOI: | 10.4314/tjpr.v19i8.29 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::854bb53ee016e798b62b6eef476f435b https://doi.org/10.4314/tjpr.v19i8.29 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........854bb53ee016e798b62b6eef476f435b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15969827 15965996 |
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| DOI: | 10.4314/tjpr.v19i8.29 |